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2012年基礎実習学生

研究業績

論文実績
英文


小笠原康悦
 (2011年度まで)

1.      Nakayama M, Takeda K, Kawano M, Takai T, Ishii N, Ogasawara K.  NK-dendritic cell interactions generate MHC class II-dressed NK cells that regulate CD4+ T cells. Proc Natl Acad Sci U S A. in press

2.      Takeda K, Nakayama M, Sakaki M, Hayakawa Y, Imawari M, Ogasawara K, Okumura K, Smyth MJ. IFN-γ production by lung NK cells is critical for the natural resistance to pulmonary metastasis of B16 melanoma in mice. (2011) Journal of Leukocyte Biology 90(4):777-85.

3.      Matsutani T, Fujii Y, Kitaura K, Suzuki S, Tsuruta Y, Takasaki T, Ogasawara K, Nishimoto N, Kurane I, Suzuki R.  Increased positive selection pressure within the complementarity determining regions of the T-cell receptor β gene in New World monkeys. (2011) American J. Primatology 73(10):1082-92.

4.      Matsumoto K, Nishiya T, Maekawa S, Horinouchi T, Ogasawara K, Uehara T, Miwa S. The ECS(SPSB) E3 ubiquitin ligase is the master regulator of the lifetime of inducible nitric-oxide synthase. (2011)  Biochem Biophys Res Commun. 409(1):46-51.

5.      Nishiya T, Matsumoto K, Maekawa S, Kajita E, Horinouchi T, Fujimuro M, Ogasawara K, Uehara T, Miwa S.  Regulation of inducible nitric-oxide synthase by the SPRY domain- and SOCS box-containing proteins. (2011)  J Biol Chem.  286(11):9009-19.

6.      Champsaur M, Beilke JN, Ogasawara K, Koszinowski UH, Jonjic S, Lanier LL. (2010) Intact NKG2D-independent function of NK cells chronically stimulated with the NKG2D ligand Rae-1. J Immunol. 185(1):157-65.

7.      Honda T, Nakajima S, Egawa G, Ogasawara K, Malissen B, Miyachi Y, Kabashima K. Compensatory role of Langerhans cells and langerin-positive dermal dendritic cells in the sensitization phase of murine contact hypersensitivity J Allergy Clin Immunol 125(5):1154-1156.e2.

8.      Mori T, Ishida K, Mukumoto S, Yamada Y, Imokawa G, Kabashima K, Bito T, Nakamura M, Ogasawara K, Tokura Y.  Comparison of skin barrier  function and sensory nerve electric current perception threshold between  IgE-high extrinsic and IgE-normal intrinsic types of atopic  dermatitis Br J Dermatol 162(1):83-90.

9.      Vilarinho S, Ogasawara K, Nishimura S, Lanier LL, Baron JL. (2007) Blockade of NKG2D on NKT cells prevents hepatitis and the acute immune response to hepatitis B virus.  Proc Natl Acad Sci U S A. 104(46):18187-92.

10.    Ogasawara K, Lanier L L. (2006)  NKG2D in NK and T cell-mediated Immunity. Clin J Immunol ; 25(6):534-40.

11.    Fujiwara N, Hidano S, Mamada H, Ogasawara K, Kitamura D, Cooper MD, Hozumi N, Chen CL, Goitsuka R. (2006) A novel avian homologue of CD72, chB1r, down modulates BCR-mediated activation signals.  Int Immunol 18(5):775-83

12.    Ogasawara K, Benjamin J, Takaki R, Phillips J H, Lanier L L. (2005)  Function of NKG2D in natural killer cell-mediated rejection of mouse bone marrow grafts.   Nat Immunol 6(9):938-945.

13.    Richie Ehrlich L. I., Ogasawara K., Hamerman J. A., Takaki R., Zingoni A., Allison J. P., Lanier L. L. (2005)  Engagement of NKG2D by cognate ligand or antibody alone is insufficient to mediate costimulation of human and mouse CD8+T cells.  J Immunol 174(4):1922-31.

14.    Takeda K, Cretney E, Hayakawa Y, Ota T, Akiba H, Ogasawara K, Yagita H, Kinoshita K, Okumura K, Smyth MJ. (2005)  TRAIL identifies immature natural killer cells in newborn mice and adult mouse liver.  Blood 105(5):2082-9.

15.    Hamerman J. A., Ogasawara K., Lanier L. L. (2005)  NK cells in innate immunity.  Cur Opn Immunol ;17(1):29-35.

16.    Ota T, Takeda K, Akiba H, Hayakawa Y, Ogasawara K, Ikarashi Y, Miyake S, Wakasugi H, Yamamura T, Kronenberg M, Raulet DH, Kinoshita K, Yagita H, Smyth MJ, Okumura K. (2005)  IFN--mediated negative feedback regulation of NKT cell function by CD94/NKG2.  Blood 106 (1): 184-192.

17.    Ogasawara K., Hamerman J. A., Ehrlich L.R., Jordan H., Bluestone J. A., Lanier L. L. (2004)  NKG2D blockade prevents autoimmune diabetes in NOD mice.  Immunity 20: 757-767.

18.    Humphrey M.B., Ogasawara K., Yao W., Spusta S.C., Daws M.R., Lane N.E., Lanier L.L., Nakamura M.C. (2004)  The Signaling Adapter Protein DAP12 Regulates Multinucleation During Osteoclast Development.  Journal of Bone Miner Res. (2): 224-234.

19.    Shiratori I, Ogasawara K, Saito T, Lanier LL, Arase H. (2004)  Activation of innate immunity upon recognition of a novel CD99-like ligand by PILR.  J. Exp. Med. 199: (4) 525-533

20.    Hamerman J.A., Ogasawara K., Lanier L.L. (2004) Toll-like receptor signaling in macrophages induces ligands for the NKG2D receptor.  J Immunol 172 (4) : 2001-2005

21.    Ogasawara K., Hamerman J. A., Hsin H., Chikuma S, Jordan H., Chen T., Pertel T., Carnaud C., Bluestone J. A., Lanier L. L. (2003)  Impairment of NK cell function by NKG2D modulation in NOD mice.  Immunity 18: 41-51.

22.    Lodoen, M., Ogasawara K, Hamerman J.A., Arase H., Houchins J. P., Mocarski E.S., and Lanier L.L. (2003). NKG2D-mediated NK cell protection against cytomegalovirus is impaired by gp40 modulation of RAE-1 molecules.  J. Exp. Med 197: 1245-1253.

23.    Zompi S, Hamerman J.A, Ogasawara K, Schweighoffer E, Tybulewicz V.L.J, Di Santo JP, Lanier LL, and Colucci F. (2003)  The NKG2D receptor triggers cytotoxicity but not cytotokine production in mouse Natural killer cells lacking DAP12 or Syk tyrosine kinases.  Nat Immunol 4: 565-572.

24.    Ogasawara, K., Yoshinaga, S. K., Lanier, L. L.  (2002)  Inducible Costimulator Costimulates Cytotoxic Activity and IFN-gamma Production in Activated Murine NK Cells. J Immunol 169: 3676-3685

25.    Ogasawara K, Hida S, Weng Y, Saiura A, Sato K, Takayanagi H, Sakaguchi S, Yokichi T, Kodama T, Naitoh M, De Martino JA, Taniguchi T. (2002)  Requirement of the IFN--induced CXCR3 chemokine signaling for CD8+ T cell activation.  Genes Cells 7:309-320

26.    Taniguchi T, Ogasawara K, Takaoka A, Tanaka N. (2001)  IRF family of transcription factors as regulators of host defense.  Annu Rev Immunol 19:623-655

27.    Wakui M, Yamaguchi A, Sakurai D, Ogasawara K, Yokochi T, Tsuchiya N, Ikeda Y, Tokunaga K. (2001)  Genes highly expressed in the early phase of murine graft-versus-host reaction. Biochem Biophys Res Commun 282: 200-206

28.    Sato K, Hida S, Takayanagi H, Yokochi T, Kayagaki N, Takeda K, Yagita H, Okumura K, Tanaka N Taniguchi T, Ogasawara K. (2001)  Antiviral response by natural killer cells through TRAIL gene induction by IFN- Eur J Immunol 11:3138-3146

29.    Sato M, Suemori H, Hata N, Asagiri M, Ogasawara K, Nakao K, Nakaya T, Katsuki M, Noguchi S, Tanaka N, Taniguchi T.(2000)  Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-a/b gene induction.  Immunity 13:539-548

30.    Nakagawa T, Setou M, Seog D, Ogasawara K, Dohmae N, Takio K, Hirokawa N. (2000) A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex.  Cell 103:569-581

31.    Hida S*, Ogasawara K*, Sato K, Abe M, Takayanagi H, Yokochi T, Sato T, Hirose S, Shirai T, Taki S, Taniguchi T. (2000) CD8+ T cell-mediated skin disease in mice lacking IRF-2, the transcriptional attenuator of interferon-a/b signaling.  Immunity 13:643-655. *The first two authors are equal contributors.

32.    Takayanagi H, Ogasawara K, Hida S, Chiba T, Murata S, Sato K, Takaoka A, Yokochi T, Oda H, Tanaka K, Nakamura K, Taniguchi T. (2000)  T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-g.  Nature 408:600-605

33.    Nozawa H, Oda E, Nakao K, Ishihara M, Ueda S, Yokochi T, Ogasawara K, Nakatsuru Y, Shimizu S, Ohira Y, Hioki K, Aizawa S, Ishikawa T, Katsuki M, Muto T, Taniguchi T, Tanaka N. (1999). Loss of transcription factor IRF-1 affects tumor susceptibility in mice carrying the Ha-ras transgene or nullizygosity for p53. Genes Dev 13(10):1240-1245

34.    Taniguchi T, Tanaka N, Ogasawara K, Taki S, Sato M, Takaoka A. (1999)  Transcription factor IRF-1 and its family members in the regulation of host defense. Cold Spring Harb Symp Quant Biol 64:465-472

35.    Taniguchi, T., Tanaka, N., Ogasawara, K., Hida, S., Sato, M. and Takaoka, A. (1999)   Regulation of interferon and immune systems by the IRF family of transcription factors.  J. Interferon and Cytokine Res., 19(Sup. 1), S55.

36.    Ogasawara K, Hida S, Azimi N, Tagaya Y, Sato T, Yokochi-Fukuda T, Waldmann T.A, Taniguchi T, Taki S. (1998). Requirement for IRF-1 in the microenvironment supporting natural killer cell development. Nature 391: 700-703

37.    Ogasawara K, Takeda K, Hashimoto W,Satoh M, Okuyama R, Yanai N, Obinata M, Kumagai K, Takada H, Hiraide H, Seki S. (1998). Involvement of NK1.1+T cells and their IFN- production in the generalized Shwartzman reaction. J Immunol 160 (7): 3522-3527

38.    Fujii H, Ogasawara K, Otsuka H, Suzuki M, Yamamura K, Yokochi T, Miyazaki T, Suzuki H, Mak TW, Taki S, Taniguchi T. (1998). Functional dissection of the cytoplasmic subregions of the IL-2 receptor c chain in primary lymphocyte populations. EMBO J 17(22):6551-6557

39.    Taki S, Sato T, Ogasawara K, Fukuda T, Sato M, Hida S, Suzuki G, Mitsuyama M, Shin EH, Kojima S, Taniguchi T, Asano Y. (1997). Multistage regulation of Th1-type immune responses by the transcription factor IRF-1. Immunity 6 (6):673-679

40.    Kumagai K, Takeda K, Hashimoto W, Seki S, Ogasawara K, Anzai R, Takahashi M, Sato M, Rikiishi H. Interleukin-12 as an inducer of cytotoxic effectors in anti-tumor immunity. Int Rev Immunol 14(2-3):229-256, 1997

41.    Seki S, Hashimoto W, Ogasawara K, Satoh M, Watanabe H, Habu Y, Hiraide H, Takeda K. (1997). Antimetastatic effect of NK1+T cells on experimental haematogenous tumour metastases in the liver and lungs of mice. Immunology 92 (4): 561-566

42.    Takahashi M*, Ogasawara K*, Takeda K, Hashimoto W, Sakihara H, Kumagai K, Anzai R, Satoh M, Seki S. (1996). LPS induces NK1.1+ ab T cells with potent cytotoxicity in the liver of mice via production of IL-12 from Kupffer cells. J Immunol 156(7):2436-2442  *The first two authors are equal contributors.

43.    Takeda K, Seki S, Ogasawara K, Anzai R, Hashimoto W, Sugiura K, Takahashi M, Satoh M, Kumagai K. (1996). Liver NK1.1+ CD4+ ab T cells activated by IL-12 as a major effector in inhibition of experimental tumor metastasis. J Immunol 156(9):3366-3373

44.    Anzai R, Seki S, Ogasawara K, Hashimoto W, Sugiura K, Sato M, Kumagai K, Takeda K. (1996). Interleukin-12 induces cytotoxic NK1+  ab T cells in the lungs of euthymic and athymic mice. Immunology 8 (1):82-89

45.    Satoh M, Seki S, Hashimoto W, Ogasawara K, Kobayashi T, Kumagai K, Matsuno S, Takeda K. (1996). Cytotoxic ab or gd T cells with a natural killer cell marker, CD56, induced from human peripheral blood lymphocytes by a combination of IL-12 and IL-2. J Immunol 157(9):3886-3892

46.    Hashimoto W, Takeda K, Anzai R, Ogasawara K, Sakihara H, Sugiura K, Seki S, Kumagai K. (1995). Cytotoxic NK1.1 Ag+ ab T cells with intermediate TCR induced in the liver of mice by IL-12. J Immunol 154(9):4333-4340

 

中山勝文

47.    Nakayama M, Takeda K, Kawano M, Takai T, Ishii N, Ogasawara K.  NK-dendritic cell interactions generate MHC class II-dressed NK cells that regulate CD4+ T cells. Proc Natl Acad Sci U S A. in press

48.    Takeda K, Nakayama M, Sakaki M, Hayakawa Y, Imawari M, Ogasawara K, Okumura K, Smyth MJ. IFN-γ production by lung NK cells is critical for the natural resistance to pulmonary metastasis of B16 melanoma in mice. (2011) Journal of Leukocyte Biology 90(4):777-85.

49.    Nakayama M, Akiba H, Takeda K, Kojima Y, Hashiguchi M, Azuma M, Yagita H, and Okumura K. Tim-3 mediates phagocytosis of apoptotic cells and the cross-presentation. Blood, 113, 3821-3830, 2009

50.    Ebihara N, Nakayama M, Tokura T, Ushio H, Murakami A. Expression and function of fibroblast growth factor-inducible 14 human corneal myofibroblasts. Exp. Eye Res. 89, 256-262, 2009

51.    Ebihara N, Nakayama M, Tokura T, Iwatsu M, Ushio H, Murakami A. Proinflammatory effect of TWEAK/Fn14 interaction in human retinal pigment epithelial cells. Curr. Eye Res. 34, 836-844, 2009

52.    Nakajima A, Kojima Y, Nakayama M, Yagita H, Okumura K, Nakano H. Downregulation of c-FLIP promotes caspase-dependent JNK activation and reactive oxygen species accumulation in tumor cells. Oncogene, 27, 76-84, 2008

53.    Nakayama M, Underhill DM, Petersen TW, Li B, Kitamura T, Takai T, Aderem A. Paired immunoglobulin-like receptors bind to bacteria and shape TLR-mediated cytokine production. J. Immunol. 178, 4350-4259, 2007

54.    Kaduka Y, Takeda K, Nakayama M, Kinoshita K, Yagita H, Okumura K. TWEAK mediates anti-tumor effect of tumor-infiltrating macrophage. Biochem Biophys. Res. Commun. 331, 384-390, 2005

55.    Jin L, Nakao A, Nakayama M, Yamaguchi N, Kojima Y, Nakano N, Tsuboi R, Okumura K, Yagita H, Ogawa H. Induction of RANTES by TWEAK/Fn14 interaction in human keratinocytes. J. Invest. Dermatol. 2004,122,1175-1179

56.    Saitoh T, Nakayama M, Nakano H, Yagita H, Yamamoto N, Yamaoka S. TWEAK induces NF-kappaB2 p100 processing and long lasting NF-kappaB activation. J. Biol. Chem. 278, 36005-36012,2003

57.    Nakayama M, Ishidoh K, Kojima Y, Harada N, Kominami E, Okumura K, Yagita H. Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death. J. Immunol. 170, 341-348, 2003

58.    Nakayama M, Harada N, Okumura K, Yagita H. Characterization of murine TWEAK and its receptor (Fn14) by monoclonal antibodies. Biochem. Biophys. Res. Commun. 306, 819-825, 2003

59.    Harada N, Nakayama M, Nakano H, Fukuchi Y, Yagita H, Okumura K. Pro-inflammatory effect of TWEAK/Fn14 interaction on human umbilical vein endothelial cells. Biochem. Biophys. Res. Commun. 306, 819-825, 2003

60.    Nakayama M, Ishidoh K, Kayagaki N, Kojima Y, Yamaguchi N, Nakano H, Kominami E, Okumura K, Yagita H. Multiple pathways of TWEAK-induced cell death. J. Immunol. 168, 734-743, 2002

61.    Nakayama M, Kayagaki N, Yamaguchi N, Okumura K, Yagita H. Involvement of TWEAK in interferon gamma-stimulated monocyte cytotoxicity. J. Exp. Med. 192, 1373-1380, 2000

62.    Nagao F, Nakayama M, Muto T, Okumura K. Effects of a fermented milk drink containing Lactobacillus casei strain Shirota on the immune system in healthy human subjects. Biosci. Biotechnol. Biochem. 64, 2706-2708, 2000

63.    Kayagaki N, Yamaguchi N, Nakayama M, Takeda K, Akiba H, Tsutsui H, Okamura H, Nakanishi K, Okumura K, Yagita H. Expression and function of TNF-related apoptosis-inducing ligand on murine activated NK cells. J. Immunol. 163, 1906-1913, 1999

64.    Kayagaki N, Yamaguchi N, Nakayama M, Eto H, Okumura K, Yagita H.Type I interferons (IFNs) regulate tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression on human T cells: A novel mechanism for the antitumor effects of type I IFNs. J. Exp. Med. 189, 1451-1460, 1999

65.    Kayagaki N, Yamaguchi N, Nakayama M, Kawasaki A, Akiba H, Okumura K, Yagita H. Involvement of TNF-related apoptosis-inducing ligand in human CD4+ T cell-mediated cytotoxicity. J. Immunol. 162, 2639-2647, 1999

66.    Degawa M, Nakayama M, Konno Y, Masubuchi K, Yamazoe Y.2-Methoxy-4-nitroaniline and its isomers induce cytochrome P4501A (CYP1A) enzymes with different selectivities in the rat liver. Biochim. Biophys. Acta.1379:391-398, 1998

67.    Uehara N, Iwahori Y, Asamoto M, Baba-Toriyama H, Iigo M, Ochiai M, Nagao M, Nakayama M, Degawa M, Matsumoto K, Hirono I, Beppu H, Fujita K, Tsuda H. Decreased levels of 2-amino-3-methylimidazo[4,5-f]quinoline-DNA adducts in rats treated with beta-carotene, alpha-tocopherol and freeze-dried aloe. Jpn. J. Cancer Res. 1996;87:342-348

68.    Degawa M, Nakayama M, Yoshinari K, Hashimoto Y. 2-Methoxy-4-nitroaniline is a selective inducer of cytochrome P450IA2 (CYP1A2) in rat liver. Cancer Lett.96:95-98, 1995

 

川野光子

69.    Nakayama M, Takeda K, Kawano M, Takai T, Ishii N, Ogasawara K.  NK-dendritic cell interactions generate MHC class II-dressed NK cells that regulate CD4+ T cells. Proc Natl Acad Sci U S A. in press

70.    Mitsuko Kawano, Junkyu Han, Mohamed Elyes Kchouk and Hiroko Isoda: Hair growth regulation by the extract of aromatic plant Erica multiflora. J. Nat. Med. 63: 335-339 (2009)

71.    Terence P.N. Talorete, Atef Limam, Mitsuko Kawano, Amel Ben Rejeb Jenhani, Ahmed Ghrabi and Hiroko Isoda: Stress response of mammalian cells incubated with landfill leachate. Environ. Toxicol. Chem. 27: 1084-1092 (2008)

72.    Mitsuko Kawano, Kyoko Matsuyama, Yusaku Miyamae, Hiroshi Shinmoto, Mohamed Elyes Kchouk, Takahiro Morio, Hideyuki Shigemori and Hiroko Isoda: Antimelanohenesis effect of Tunisian herb Thymelaea hirsuta extract on B16 murine melanoma cells. Exp. Dermatol. 16: 977-984 (2007)

73.    Atef Limam, Terence P.N. Talorete, Mourad Ben Sik Ali, Mitsuko Kawano, Amel Ben Rejed Jenhani, Yukuo Abe, Ahmed Ghrabi and Hiroko Isoda: Assesment of estrogenic activity in Tunisian water and wastewater by the E-Screen assay. Environ. Sci. 14: 43-52 (2007)

74.    Mitsuko Kawano, Toru Imamura and Hiroko Isoda: Methods for searching and evaluating effective hair growth regulation factors from Tunisian samples. Journal of Arid Land Studies. 15-4: 443-446. (2006)

75.    Akiko Komi-Kuramochi, Mitsuko Kawano, Masahiro Asada, Masashi Suzuki, Junko Oki and Toru Imamura: Expression of fibroblast growth factors and their receptors during full-thickness skin wound healing in young and aged mice. J. Endocrinol. 186: 273-289 (2005)

76.    Mitsuko Kawano, Akiko Komi-Kuramochi, Masahiro Asada, Masashi Suzuki, Junko Oki, Ju Jiang and Toru Imamura: Comprehensive analysis of FGF and FGFR expression in skin: FGF18 is highly expressed in hair follicles and capable of inducing anagen from telogen stage hair follicles. J. Invest. Dermatol. 124: 877-885. (2005)

77.    Mitsuko Kawano, Satoshi Suzuki, Masashi Suzuki, Junko Oki, and Toru Imamura: Bulge- and basal layer- specific expression of fibroblast growth factor-13 (FHF-2) in mouse skin. J. Invest. Dermatol. 122:1084-1090. (2004)

78.    Yutaka Ota, Yuko Saitoh, Satoshi Suzuki, Kazuo Ozawa, Mitsuko Kawano, and Toru Imamura: Fibroblast growth factor 5 inhibits hair growth by blocking dermal papilla cell activation. Biochem. Biophys. Res. Comm. 290:169-176. (2002)

79.    Mitsuko Kawano and Tomohiko Kuwabara: pH-dependent reversible inhibition of violaxanthin de-epoxidase by pepstatin related to protonation-induced structural change of the enzyme. FEBS Lett. 481:101-104. (2000)

80.    Tomohiko Kuwabara, Mika Hasegawa, Mitsuko Kawano, and Shinichi Takaichi: Characterization of violaxanthin de-epoxidase purified in the presence of Tween 20: effects of dithiothreitol and pepstatin A. Plant Cell Physiol. 40:1119-1126. (1999)

 

日本語総説、著書、翻訳

小笠原康悦

1.      小笠原康悦 NK受容体による認識 標準免疫学 第3

2.      川野光子、小笠原康悦 金属アレルギーの免疫学Up-to-date Visual Dermatorogy 10(11) 1208-1212. 2011

3.      Anthony L. DeFranco, Richard M. Locksley, Miranda Robertson  Immunity -The Immune Response in Infectious and Inflammatory Disease  Chapter 8, Specialized Lymphocytes in Early Responses and Homeostasis Oxford University Press  (翻訳:小笠原康悦, 監訳:笹月健彦) 2008

4.      Ogasawara K  NK activating receptor in autoimmune diabetes  Frontiers in Rheumatology & Clinical Immunology 2008

5.      小笠原康悦  発症にかかわる免疫異常  新時代の糖尿病学(1)2008

6.      小笠原康悦  自然免疫と適応免疫を繋ぐNK細胞群:The Frontiers in Medical Sciences 「免疫応答と免疫病態の統合的分子理解に向けて」2007

7.      小笠原康悦  NK細胞の制御シグナルと疾患:実験医学 Vol 25 1282-1285 2007

8.      Lewis L. Lanier (翻訳:小笠原康悦)  NK活性化レセプター複合体:実験医学 Vol 25 1287-1292  2007

9.      石崎和沙、小笠原康悦 NK細胞活性化レセプターNKG2Dの生体内における機能:実験医学 Vol 25 1321-1325 2007

10.    小笠原康悦、藤原成芳 自己免疫性糖尿病におけるNK活性化レセプターNKG2D:感染 炎症 免疫 Vol 36-2 60-62  2006

11.    小笠原康悦 骨髄移植拒絶に関わるNK細胞の標的分子の発見:細胞工学 1312-1313 2005

12.    小笠原康悦, 藤原成芳 1型糖尿病における NKG2Dの役割 :免疫2006 301-307  2005

13.    小笠原康悦 1型糖尿病におけるNK活性化レセプターを介した膵細胞障害機構:内分泌、糖尿病科  Vol: 20 (5) 444-451 2005

14.    小笠原康悦 NKG2Dとそのリガンドの機能と役割:Annual Review 免疫 2005 102-109 2004

15.    小笠原康悦、佐藤充治 インターフェロンと生体防御:バイオサイエンスの新世紀 12巻 第11章 2000 

16.    小笠原康悦 IL-15によるNK細胞の分化、活性化とそのシグナル :Annual Review 免疫 2000   146-154 1999

17.    小笠原康悦 NK細胞の発生分化とサイトカイン:臨床免疫  vol. 31 no. 1  1-6 1999

18.    小笠原康悦  IRF-1IL-15NK細胞分化:炎症と免疫 巻号:vol. 7 no.5 27-35  1999

19.    小笠原康悦 免疫系におけるIRF-1の役割:臨床遺伝学99 免疫研究の最前線  9月増刊 90-99 1999

20.    小笠原康悦、瀧伸介 NK細胞の分化における転写因子IRF-1の役割:免疫1998-1999 中山書店 臨時増刊 166-174 1998

21.    肥田重明、小笠原康悦、瀧伸介  NK細胞の分化におけるIRF-1IL-15の機能:組織培養工学  巻号:vol. 24 no. 9  18-21 1998

22.    小笠原康悦  転写因子IRF-1によるNK細胞の分化制御機構:Immunology Frontier  vol. 8 no. 6  42-46  1998

23.    竹田和由、小笠原康悦、熊谷勝男  フローサイトメトリーによる接着因子(CD44)の検出:続 がんの浸潤・転移研究マニュアル がん転移研究会 金芳堂 88-90  1997

24.    小笠原康悦、熊谷勝男  癌転移と接着分子ーCD44を中心としてー.Oncology and Chemotherapy  vol.10 No.1  22-27 1994

25.    力石秀実、小笠原康悦、熊谷勝男  肺転移を制御する接着分子CD44.:実験医学 11  52-57 1993

 

中山勝文

26.    中山勝文Timファミリー分子を介したアポトーシス細胞貪食機構 生物と化学 201012月 日本農芸化学会 会誌

27.    垣生園子、中山勝文:免疫学研究者のための道具箱 翻訳 免疫生物学(原著第7版)20104月 南江堂

28.    中山勝文TWEAK、サイトカイン・増殖因子用語ライブラリー 2005 年 羊土社

29.    中山勝文、八木田秀雄、奥村康:細胞死誘導性TNFファミリー分子を介したキラー細胞の標的細胞破壊機構 炎症・再生 2332003年 日本炎症・再生医学会 会誌

30.    中山勝文、奥村康:キラー細胞、アレルギーリウマチ膠原病の最新治療医療 20032月 先端技術研究所 

31.    中山勝文、八木田秀雄、奥村康:TWEAK アポトーシスのすべて 臨床免疫 382002年 科学論評社 

32.    中山勝文TWEAK/Fn14レセプターシステム 医学のあゆみ203 72002年 医歯薬出版株式会社

33.    中山勝文、榧垣伸彦、八木田秀雄:アポトーシスと免疫系 アポトーシスと疾患 20006月 医薬ジャーナル社

 

川野光子 

34.    川野光子、小笠原康悦 金属アレルギーの免疫学Up-to-date Visual Dermatorogy 10(11) 1208-1212. 2011

川野光子  公開特許

国内出願

35.    礒田博子、川野光子、森尾貴広、モハメド・エリス・シュック、繁森英幸  特許公開2008-179598号(200887日公開)「Thymelaea属植物からの抽出物を有効成分とするメラニン産生抑制剤、及びこれを含有する美白用の医薬品組成物、化粧料組成物、並びに食品」

36.    礒田博子、川野光子、森尾貴広、モハメド・エリス・シュック  特許公開2008-179599号(200887日公開)「ツツジ科エリカ属植物由来成分を少なくとも含む外皮系組織用組成物」

37.    礒田博子、ハン ジュンキュ、川野光子、森尾貴広、モハメド・エリス・シュック 特許公開2008-1629272008718日公開)「神経細胞保護剤、及びこれを含有する医薬品組成物、化粧料組成物並びに食品」

38.    今村亨、倉持明子、川野光子、織田裕子  特許公開2006-34797920061228日公開)「創傷治療及び/又は創傷治癒促進のための薬剤」

39.    今村亨、川野光子、倉持明子、鈴木理  特許公開2006-830822006330日公開)「毛髪成長促進剤、発毛促進剤及び脱毛症治療剤」

40.    今村亨、川野光子、鈴木理  特許公開2005-31438620051110日公開)「動物臓器から抽出した水溶性画分、その製造方法、逆転写反応阻害剤、逆転写酵素阻害剤、ウイルス増殖阻害剤及び医薬組成物」

41.    今村亨、鈴木理、川野光子、倉持明子、隠岐潤子、鈴木聡  特許公開2005-735242005324日公開)「幹細胞の標識方法、分離方法、活性制御方法並びに皮膚組織の作製方法」

PCT出願

42.    今村亨、倉持明子、川野光子、織田裕子、浅田眞弘、鈴木理、隠岐潤子、辻野望  WO 2006/135027 A120061221日国際公開)「創傷治療及び/又は創傷治癒促進のための薬剤」

43.    今村亨、川野光子、倉持明子、鈴木理、浅田眞弘  WO 2006/030693 A12006323日国際公開)「毛髪問題治療剤、及びそのスクリーニング方法」

44.    今村亨、川野光子、鈴木理  WO 2005/094851 A120051013日国際公開)「動物臓器から抽出した水溶性画分、その製造方法、逆転写反応阻害剤、逆転写酵素阻害剤、ウイルス増殖阻害剤及び医薬組成物」



受賞・メディア紹介
2006年4月 文部科学大臣表彰若手科学者賞 受賞
「免疫学分野におけるNK細胞の標的細胞認識機構の研究」
2006年4月

Human Frontier Science Program Career Development Award 受賞
"Role of NKG2D and its ligands in autoimmune diabetes"

2006年12月

日本免疫学会研究奨励賞 受賞

「NK細胞認識機構の研究」
2006年11月

日本白血病研究基金 クレディセゾン賞 受賞 

「造血幹細胞移植におけるNK関連分子の役割」
2005年3月

東京免疫フォーラム研究奨励賞 受賞

「自己免疫性糖尿病におけるNKG2Dの機能と役割」

2005年1月

Abbott Bioresearch Center Fellow Award 受賞

"Role of NKG2D and its ligands in autoimmune diabetes"
2005年1月

Irvington Institute Fellow Award 受賞
"Role of NKG2D and its ligands in autoimmune diabetes"

2003年5月

山下太郎学術研究奨励賞 受賞

「免疫細胞の分化および機能抑制機構の解明」

2001年4月

Human Frontier Science Program LTF award 受賞

"Analysis of ITAM receptors in NK cell function"

   
   

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