業績リスト

論文

1) Chagan-Yasutan H, Tsukasaki K, Takahashi Y, Oguma S, Harigae H, Ishii N, Zhang J, Fukumoto M, Toshio Hattori T: Involvement of osteopontin and its signaling molecule CD44 in clinicopathological features of adult T cell leukemia. Leukemia Res 2011.
2) Kuwahara Y, Oikawa T, Ochiai Y, Roudkenar MH, Fukumoto M, Shimura T, Ohtake Y, Ohkubo Y, Mori S, Uchiyama Y, Fukumoto M: Enhancement of autophagy is a potential modality for tumors refractory to radiotherapy. Cell Death Dis 2011(accepted for publication).
3) Roudkenar MH, Halabian R, Bahmani P, Roushandeh AM, Kuwahara Y, Fukumoto M: Neutrophil gelatinase-associated lipocalin: A new antioxidant that exerts its cytoprotective effect independent on Heme Oxygenase-1. Free Radic Res. 2011 May 5. [Epub ahead of print]
4) Shimura T, Umata , Kuwahara Y, FukumotoM: Identification and analysis of biological markers for tritium exposure. Fusion Sci Technol (Suppl), 2011.
5) Shimura T, Kakuda S, Ochiai Y, KuwaharaY, Takai Y, Fukumoto M: Targeting the AKT/GSK3β/cyclin D1/Cdk4 survival signaling pathway for eradication of tumor radioresistance acquired by fractionated radiotherapy. Int J Radiat Oncol Biol Phys 80(2):540-8, 2011.
6) Saito K, Kakizaki T, Hayashi R, Nishimaru H, Furukawa T, Nakazato Y, Takamori S, Ebihara S, Uematsu M, Mishina M, Miyazaki J, Yokoyama M, Konishi S, Inoue K, Fukuda A, Fukumoto M, Nakamura K, Obata K, Yanagawa Y.The physiological roles of vesicular GABA transporter during embryonic development: a study using knockout mice. Mol Brain 3:40 (open access), 2010.
7) Li L, Hashiyada M, Kume M, Fukumoto M, Yamamoto Y, Funayama M, Yamamoto Y, Fukumoto M. A case of hepatocellular carcinoma developed after allogeneic bone marrow transplantation. Pathol Int 60(12):795-7, 2010.
8) Kodama T, Aoi A, Watanabe Y, Horie S, KodamaM, Li L, Chen R, Teramoto N, Morikawa H, Mori S, Fukumoto M: Evaluation of transfection efficiency in skeletal muscle using nano/microbubbles and ultrasound. Ultrasound Med Biol 36(7):1196-205, 2010.
9) Shimura T, Kakuda S, Ochiai Y, Nakagawa H, Kuwahara Y, Takai Y, Kobayashi J, Komatsu K, Fukumoto M: Acquired radioresistance of human tumor cells by DNA-PK/AKT/GSK3β-mediated cyclinD1 overexpression. Oncogene 29(34):4826-37, 2010.
10) Kuwahara Y, Mori M, Oikawa T, Shimura T, Ohtake Y, Mori S, Ohkubo Y, Fukumoto M: The modified high-density survival assay is the useful tool to predict the effectiveness of fractionated radiation exposure. J Radiat Res 51(3):297-302, 2010.
11) Yamamoto Y, Usuda N, Ohgiso Y, Kuwahara Y, Fukumoto M: The uneven irradiation of a target cell and its dynamic movement can mathematically explain incubation period for the induction of cancer by internally deposited radionuclides. Health Phys 99(3):388-93, 2010.
12) Wong WF, Nakazato M, Watanabe T, Kohu K, Ogata T, Yoshida N, Sotomaru Y, Ito M, Araki K, Telfer J, Fukumoto M, Suzuki D, Sato T, Hozumi K, Habu S, Satake M: Over-expression of Runx1 transcription factor impairs the development of thymocytes from the double-negative to double-positive stages. Immunol 30(2):243-53.2010.
13) Maruko A, Ohtake Y, Kawaguchi M, Kobayashi T, Baba Y, Kuwahara Y, Nakagawa H, Shimura T, Fukumoto M, Ohkubo Y: X-irradiation-induced down-regulation of the EGF receptor in primary cultured rat hepatocytes. Radiat Res 173(5), 620-8, 2010.
14) Hidaka M, Oda S, Kuwahara Y, Fukumoto M, Mitani H. Cell lines derived from a Medaka radiation-sensitive mutant have defects in DNA double-strand break responses. J Radiat Res 51:165-71, 2010.
15) Chen C, Takahashi K, Yoshida A, Takizawa Y, Lee Y, Nakui M, Doi H, Takebayashi Y, Fukumoto M, Yamada T, Katagiri H, Oka Y, Satoh J: Characterization of a novel murine preadipocyte line, AP-18, isolated from subcutaneous tissue: analysis of adipocyte-related gene expressions. Cell Biol Int 34(3):293-9, 2010.
16) Yamamoto Y, Chikawa J, Uegaki Y, Usuda N, Kuwahara Y, Fukumoto M: Histological type of Thorotrast-induced liver tumors associated with the translocation of deposited radionuclides. Cancer Sci 101(2):336-40, 2010.
17) Nariyama N, Ohhigashi T, Umetani K, Shinohara K, Tanaka H, Maruhashi A, Kashino G, Kurihara A, Kondo T, Fukumoto M: Spectromicoscopic film dosimetry for high-energy microbeam from synchrotron radiation. Appl Rad Isot 67(1):155-9. 2009.
18) Kashino G, Kondoh T, Nariyama N, Umetani K, Ohigashi T, Shinohara K, Kurihara A, Fukumoto M, Tanaka H, Maruhashi A, Suzuki M, Kinashi Y, Yong L, Masunaga S, Watanabe M, Ono K: Inductions of DNA double strand breaks and cellular migrations through the bystander effects in the cells irradiated with slit type microplanar beam of the SPring-8 synchrotron. Int J Radiat Oncol Biol Physic 74(1):229-36.2009.
19) Kuwahara Y, Li L, Baba T, Nakagawa H, Shimura T, Yamamoto Y, Ohkubo Y, Fukumoto M: Clinically relevant radioresistant cells efficiently repair DNA double-strand breaks induced by X-rays. Cancer Sci 100(4):747-52, 2009.
20) Ohtake Y, Maruko A, Kuwahara Y, Fukumoto M, Ohkubo Y: Stabilities of 67Ga- and 111In-labeled transferrin in vitro. Protein Pept Lett 16(2):138-42, 2009.
21) Nakayama K, Nakayama N, Ishibashi M, Yeasmin S, Fukumoto M, Miyazaki K: Fractional allelic loss as a potential biomarker of risk prediction in early-stage mucinous ovarian tumors of low malignant potential. Eur J Gynaecol Oncol 30(1):16-9, 2009.
22) Yamamoto Y, Usuda N, Takatsuji T, Kuwahara Y, Fukumoto M: Long incubation period for the induction of cancer by thorotrast is attributed to the uneven irradiation of liver cells at the microscopic level. Radiat Res 71(4):494-503, 2009.
23) Chen R, Chiba M, Mori S, Fukumoto M, Kodama T: Periodontal gene transfer using ultrasound and nano-/microbubbles. J Dent Res 88(11):1008-13, 2009.
24) Kodama T, Tomita N, Horie1 S, Sax N, Iwasaki H, Suzuki R, Maruyama K, Mori S, Fukumoto M: Morphological study of acoustic liposomes using transmission electron microscopy. J Electron Microscop 1-10, 2009.
25) Ohtake Y, Maruko A, Ohishi N, Fukumoto M, Ohkubo Y: Effect of aging on EGF-induced proliferative response in primary cultured periportal and perivenous hepatocytes. J Hepatol 48(2):246-54, 2008.
26) Umemura A, Itoh Y, Itoh K, Yamaguchi K, Nakajima T, Higashitsuji H, Onoue H, Fukumoto M, Okanoue, Fujita J: Association of gankyrin protein expression with early clinical stages and IGFBP-5 expression in human hepatocellular carcinoma. Hepatol 47(2):493-502, 2008.
27) Roudkenar MH, Li L, Baba T, Kuwahara Y, Nakagawa H, Wang L, Kasaoka S, Ohkubo Y, Ono K, Fukumoto M: Gene expression profiles in mouse liver cells after exposure to different types of radiation. J Radiat Res 49(1):29-40, 2008.
28) Roudkenar MH, Bouzari S, Kuwahara Y, Roushandeh AM, Baba T, Oloomi M, Fukumoto M: Induction of apoptosis on K562 cell line and double strand breaks on colon cancer cell line expressing high affinity receptor for granulocyte macrophage-colony stimulating factor (GM-CSF). Iran Biomed J 12(1):1-6, 2008.
29) Takeyama J, Sasano H, Fukumoto M: Giant chordoma occupying the whole abdominal cavity. Pathology 40(3):313-4, 2008.
30) Li L, Shoji W, Ohshima H, Obinata M, Fukumoto M, Kanno N: Crucial role of peroxiredoxin III in placental antioxidant defense o f mice. FEBS Lett 582(16):2431-4, 2008.
31) Ishibashi M, Nakayama K, Yeasmin S, Katagiri A, Iida K, Nakayama N, Fukumoto M, Miyazaki K: A BTB/POZ gene, NAC-1, a tumor recurrence-associated gene, as a potential target for Taxol resistance in ovarian cancer. Clin Cancer Res 14(10):3149-55, 2008.
32) Nakayama N, Nakayama K, Yeasmin S, Ishibashi M, Katagiri A, Iida K, Fukumoto M, Miyazaki K. KRAS or BRAF mutation status is a useful predictor of sensitivity to MEK inhibition in ovarian cancer. Br J Cancer 99(12):2020-8, 2008.
33) Huan Z, Nakayama K, Nakayama N, Ishibashi M, Yeasmin S, Katagiri A, Purwana IN, Iida K, Maruyama R, Fukumoto M, Miyazaki K: Genetic classification of ovarian carcinoma based on microsatellite analysis: relationship to clinicopathological features and patient survival. Oncol Rep 19(3):775-81, 2008.
34) Miyashita H, Mori S, Fukumoto Y, Sato A, Fukumoto M, Kawamura H: Loss of heterozygosity of the PTH/PTHrP type 1 recptor in oral squamous cell carcinoma. Mol Med Report 1:821-5, 2008.
35) Baba T, Nishimura M, Kuwahara Y, Ueda N, Naitoh S, Kume M, Yamamoto Y, Fujita J, Funae Y, Fukumoto M: Analysis of gene and protein expression of cytochrome P450 and stress-associated molecules in rat liver after spaceflight. Pathol Int 58(9):589-95, 2008.
36) Roudkenar MH, Halabian R, Ghasemipour Z, Roushandeh AM, Rouhbakhsh M, Nekogoftar M, Kuwahara Y, Fukumoto M, Shokrgozar MA. Neutrophil gelatinase-associated lipocalin acts as a protective factor against H(2)O(2) toxicity. Arch Med Res 39(6):560-6, 2008.
37) Roudkenar MH, Li L, Baba T, Kuwahara Y, Nakagawa H, Wang L, Kasaoka S, Ohkubo Y, Ono K, Fukumoto M. Gene expression profiles in mouse liver cells after exposure to different typesof radiation. J Radiat Res 49:29-40, 2008.
38) Shimura, T., Torres, M. J., Martin, M. M., Rao, V. A., Pommier, Y., Katsura, M., Miyagawa, K., and Aladjem, M. I. (2008). Bloom's syndrome helicase and Mus81 are required to induce transient double-strand DNA breaks in response to DNA replication stress. J Mol Biol 375, 1152?64, 2008.
39) Shimura T. Martin M, Torres M.J., Gu C, Pluth J.M., DiBernardi, Scott McDonald, Mirit I. Aladjem DNA-PK is Involved in Repairing a Transient Surge of DNA Breaks Induced by Deceleration of DNA Replication J Mol Biol 767: 665-80, 2007.
40) Roudkenar MH, Bouzari S, Oolomi M, Kuwahara Y, Roushandeh MA, Baba T, Fukumoto M. Assessment of GM-CSF receptors by real-time RT-PCR on cell lines expressing high and low affinity receptors and their relation to cytotoxic effect of chimeric protein (StxA1-GM-CSF). DARU 15:151-5, 2007.
41) Miao ZH, Player A, Shankavaram U, Wang YH, Zimonjic DB, Lorenzi PL, Liao ZY, Liu H, Shimura T, Zhang HL, Meng LH, Zhang YW, Kawasaki ES, Popescu NC, Aladjem MI, Goldstein DJ, Weinstein JN, Pommier Y. Functions of Human Topoisomerase I: Genome-Wide and Pharmacologic Analyses. Cancer Res 2007 67(18): 8752-61.
42) Wang L, Kuwahara Y, Li L, Baba T, Shin RW, Ohkubo Y, Ono K, Fukumoto M . Analysis of Common Deletion (CD) and a novel deletion of mitochondrial DNA induced by ionizing radiation. Int J Radiat Biol 83:433-42, 2007.
43) Ramalingam S, Honkanen P, Young L, Shimura T, Austin J, Steeg P.S. & Nishizuka S Quantitative Assessment of the p53-Mdm2 Feedback Loop Using Protein Lysate Microarrays Cancer Res 2007 67:6247-52.
44) Roudkenar MH, Kuwahara Y, Baba T, Roushandeh AM, Ebishima S , Abe S, Ohkubo Y,Fukumoto M. Oxidative stress induced Lipocalin 2 gene expression: addressing its expression under the harmful conditions. J Radiat Res 48:39-44, 2007.
45) Adiga S.K., Toyoshima M, Shiraishi K, Shimura T, Takeda J, Taga M, Nagai H, Kumar P, Niwa O. p21 Provides Stage Specific DNA Damage Control to Preimplantation Embryos. Oncogene 2007 13: 6141-9.
46) Adiga S.K., Toyoshima M, Shimura T, Takeda J, Uematsu N, Niwa O Delayed and Stage Specific Phosphorylation of H2AX During Preimplantation Development of Gamma-Irradiated Mouse Embryos. Reproduction 2007,133: 415-22.
47) Fukumoto M, Kuwahara Y, Ohkubo Y, Wang L . Analysis of carcinogenic mechanisms of liver cancers induced by chronic exposure to alpha-particles from internally deposited Thorotrast. Radiat Meas 41:1186-90, 2006.
48) Shimura T, Toyoshima M, Adiga S.K., Kunoh T, Nagai H, Shimizu N, Inoue M and Niwa O Suppression of Replication Fork Progression in Low Dose Specific p53 Dependent S-phase DNA Damage Checkpoint. Oncogene 25; 5921-32, 2006.
49) Abe S, Nakao H, Hatakeyama K, Ohtake Y, Kojima S, Fukumoto M , Ohkubo Y. Zonal differences in gallium-67 uptakes between perivenous versus periportal regions of rat liver following carbon tetrachloride treatment. Hepatol Res 36:78-85, 2006.
50) Ohtake Y, Maruko A, Abe S, Nagashima T, Fukumoto M, Ohkubo Y. Involvement of retinoic acid-induced transglutaminase activity in zonal different hepatocyte proliferation after partial hepatectomy. J Gastroenterol Hepatol 21:1726-30, 2006.
51) Takahashi K, Akiyama H, Shimazaki K, Uchida C, Akiyama-Okunuki H, Tomita M, Fukumoto M, Uchida T. Ablation of a peptidyl prolyl isomerase Pin1 from p53-null mice accelerated thymic hyperplasia by increasing the level of the intracellular form of Notch1. Oncogene 26(26):3835-45, 2007.
52) Roudkenar MH, Bouzari S, Kuwahara Y, Roushandeh AM, Oloomi M, Fukumoto M. Recombinant hybrid protein, Shiga toxin and granulocyte macrophage colony stimulating factor effectively induce apoptosis of colon cancer cells. World J Gastroenterol 12:2341-4, 2006.
53) Ohtake Y, Maruko A, Abe S, Fukumoto M, Ohkubo Y. Effect of retinoic acid-induced transglutaminase on cell growth in regenerating liver. Biomed Res 27:75-80, 2006.
54) Sakurai T, Itoh K, Higashitsuji H, Nonoguchi K, Liu Y, Watanabe H, Nakano T, Fukumoto M, Chiba T, Fujita J. Cirp protects against tumor necrosis factor-alpha-induced apoptosis via activation of extracellular signal-regulated kinase. Biochim Biophys Acta 1763:290-5, 2006.
55) Fukumoto M, Nakayama K. Ovarian epithelial tumors with low malignant potential (LMP): Are they precursors toward ovarian carcinoma? Pathol Int 56:233-9, 2006.  
56) Tsuchiya A, Yano M, Tocharus J, Kojima H, Fukumoto M, Kawaichi M, Oka C. Expression of mouse HtrA1 serine protease in normal bone and cartilage and its upregulation in joint cartilage damaged by experimental arthritis. Bone 37:323-36, 2005.
57) Toyoshima M, Shimura T, Adiga S.K., Taga M, Shiraishi K, Inoue M, Yuan Z.M., Niwa O. Transcription-Independent Suppression of DNA Synthesis by p53 in Sperm-Irradiated Mouse Zygotes. Oncogene 24:3229-35, 2005.
58) Lee I, Lee H, Kim M, Fukumoto M, Sawada S, Jakate S, Gould V. Ethnic difference of Helicobacter pylori gastritis: Korean and Japanese gastritis is characterized by male- and antrum-predominant acute foveolitis in comparison with American gastritis. World J Gastroenterol 11:94-8, 2005.
59) Ohtake Y, Suyama S, Abe S, Sato N, Kojima S, Fukumoto M, Ohkubo Y. The involvement of polyamines as substrates of transglutaminase in zonal different hepatocyte proliferation after partial hepatectomy. Biol Pharm Bull 28:349-52, 2005.
60) Toda Y, Aoki R, Ikeda Y, Azuma Y, Kioka N, Matsuo M, Sakamoto M, Mori S, Fukumoto M, Ueda K. Detection of ABCA7-positive cells in salivary glands from patients with Sj?gren’s syndrome. Pathol Int 55:639-43, 2005.
61) Nakajima A, Yamamoto Y, Taura K, Hata K, Fukumoto M, Uchinami H, Yonezawa K, Yamaoka Y. Beneficial effect of cepharanthine on overcoming drug-resistance of hepatocellular carcinoma. Int J Oncol 24:635-45, 2004.
62) Liu D, Wada I, Tateno H, Ogino D, Li L, Wang L, Kojirto M, Fukayama M, Okabe H, Fukumoto M. Allelotypic characteristics of Thorotrast-induced intrahepatic cholangiocarcinoma: comparison to non-Thorotrast-associated liver cancers. Radiat Res 16:235-43, 2004.
63) Furukawa M, Nishimura M, Ogino D, Chiba R, Ikai I, Ueda N, Naito S, Kuribayashi S, Moustafa MA, Uchida U, Sawada H, Kamataki T, Funae Y, Fukumoto M. Cytochrome P450 Gene expressions in peripheral blood mononuclear cells in comparison with the liver. Cancer Sci 95:520-9, 2004.
64) Moustafa MA, Ogino D, Nishimura M, Ueda N, Naito S, Furukawa M, Uchida T, Ikai I, Sawada H, Fukumoto M. Comparative Analysis of ATP-binding cassette (ABC) transporter gene expressions in peripheral blood leukocytes and in the liver with hepatocellular carcinoma. Cancer Sci 95:530-6, 2004.
65) Nakayama K, Takebayashi Y, Hata K, Fujiwaki R, Iida K, Fukumoto M, Miyazaki K. Allelic loss at 19q12 and Xq11-12 predict an adverse clinical outcome in patients with mucinous ovarian tumours of low malignant potential. Br J Cancer 90:1204-10, 2004.
66) Liu D, Wada I, Tateno H, Ogino D, Li L, Wang L, Kojirto M, Fukayama M, Okabe H, Fukumoto M. Allelotypic characteristics of Thorotrast-induced intrahepatic cholangiocarcinoma: comparison to non-Thorotrast-associated liver cancers. Radiat Res 161:235-43, 2004.
67) Momoi H, Wada Y, Sarumaru S, Tamaki N, Gomi T, Kanaya S, Katayama T, Ootoshi M, Fukumoto M. Primary Osteosarcoma of the Breast. J Jpn Breast Cancer Soc. 11:396-400, 2004.
68) Furukawa M, Nishimura M, Ogino D, Chiba R, Ikai I, Ueda N, Naito S, Kuribayashi S, Moustafa M A, Uchida U, Sawada H, Kamataki T, Funae Y, Fukumoto M. Cytochrome P450 Gene expressions in peripheral blood mononuclear cells in comparison with the liver. Cancer Sci. 95:520-9, 2004.
69) Moustafa MA, Ogino D, Nishimura M, Ueda N, Naito S, Furukawa M, Uchida T, Ikai I, Sawada H, Fukumoto M. Comparative analysis of ATP-binding cassette (ABC) transporter gene expressions in peripheral blood leukocytes and in the liver with hepatocellular carcinoma. Cancer Sci. 95:530-6, 2004.
70) Nakajima A, Yamamoto Y, Taura K, Hata K, Fukumoto M, Uchinami H, Yonezawa K, Yamaoka Y. Beneficial effect of cepharanthine on overcoming drug-resistance of hepatocellular carcinoma. Int J Oncol 24:635-45, 2004.
71) Momoi H, Wada Y, Sarumaru S, Tamaki N, Gomi T, Kanaya S, Katayama T, Ootoshi M, Fukumoto M. Primary osteosarcoma of the breast. Breast Cancer 11:396-400, 2004.
72) Ohtake Y, Maruko A, Kojima S, Ono T, Nagashima T, Fukumoto M, Suyama S, Abe S, Sato N, Ohkubo Y. Zonal differences in DNA synthesis and in transglutaminase activity between perivenous versus periportal regions of regenerating rat liver. Biol Pharm Bull 27:1758-62, 2004.
73) Jang J, Lee S, Jung Y, Son K, Fukumoto M, Gould VE, Lee I. Malgun (clear) cell change in Helicobacter pylori gastritis reflects epithelial genomic damage and repair. Am J Pathol 162:1203-11, 2003.
74) Nakayama K, Takebayashi Y, Hata K, Fujiwaki R, Iida K, Fukumoto M, Miyazaki K. The proliferative activity of ovarian tumors of low malignant potential differs from that of ovarian carcinoma. Anticancer Res 23:4657-62, 2003.
75) Kuwahara Y, Shimada A, Mitani H, Shima A. γ-ray exposure accelerates spermatogenesis of medaka fish, Oryzias latipes. Mol Reprod Dev 65:204-11, 2003.
76) Miyashita H, Mori S, Motegi K, Fukumoto M, Uchida T. Pin1 is overexpressed in oral squamous cell carcinoma and its levels correlate with cyclin D1 overexpression. Oncol Report 10:455-61, 2003.
77) Jang J, Lee S, Jung Y, Son K, Fukumoto M, Gould VE, Lee I. Malgun (clear) cell change in Helicobacter pylori gastritis reflects epithelial genomic damage and repair. Am J Pathol 162:1203-11, 2003.
78) Kono K, Ueba T, Takahashi JA, Murai N, Hashimoto N, Myoumoto A, Itoh N, Fukumoto M. In vitro growth suppression of human glioma cells by a 16-mer oligopeptide: a potential new treatment modality for malignant glioma. J Neurooncol. 63:163-71, 2003.
79) Nakayama S, Nakayama K, Takebayashi Y, Hata K, Fujiwaki R, Fukumoto M, Miyazaki K: Allelotypes as potential prognostic markers in ovarian carcinoma treated with cisplatin-based chemotherapy. Int J Mol Med 11:621-5, 2003.
80) Nakayama K, Takebayashi Y, Hata K, Fujiwaki R, Iida K, Fukumoto M, Miyazaki K. The proliferative activity of ovarian tumors of low malignant potential differs from that of ovarian carcinoma. Anticancer Res 23:4657-62, 2003.
81) Nakayama K, Takebayashi Y, Nakayama S, Hata K, Fujiwaki R, Fukumoto M, Miyazaki K: Prognostic value of overexpression of p53 in human ovarian carcinoma patients receiving cisplatin. Cancer Lett 192: 227-35, 2003.
82) Kono K, Ueba T, Takahashi JA, Murai N, Hashimoto N, Myoumoto A, Itoh N, Fukumoto M. In vitro growth suppression of human glioma cells by a 16-mer oligopeptide: a potential new treatment modality for malignant glioma. J Neurooncol 63:163-71, 2003.
83) Shimada T, Suzuki H, Motohara M, Kuwata T, Ibuki K, Ui M, Iida T, Fukumoto M, Miura T, Hayami M: Comparative histopathological studies in the early stages of acite pathogenic and nonpathogenic SHIV-infected lymphoid organs. Virol 306: 334-46, 2003.
84) Shimura T, Toyoshima M, Taga M, Shiraishi K, Uematsu N, Inoue M and Niwa O : The novel Surveillance Mechanism of the Trp53-dependent S-phase Checkpoint Ensures Chromosome Damage Repair and Preimplantation-Stage Development of Mouse Embryos Fertilized with Xiirradiated Sperm. Radiation Res 158: 735-42, 2002.
85) Shiraishi K, shimura T, Taga M, Uematsu N, Condo Y, Ohtaki M, Niwa O Long Term Activation of Untargeted Mutagenesis at the Pink-eyed Dilution Locus in F1 Mice Born to Irradiated Spermatozoa. Radiation Res 157: 661-7, 2002.
86) Nakayama S, Nakayama K, Takebayashi Y, Hata K, Fujiwaki R, Fukumoto M, Miyazaki K. Allelotypes as potential prognostic markers in ovarian carcinoma treated with cisplatin-based chemotherapy. Int J Mol Med 11:621-5, 2003.
87) Kuwahara Y, Shimada A, Mitani H, Shima A. A critical stage in spermatogenesis for radiation-induced cell death in the medaka fish, Oryzias latipes. Radiat Res 157:386-92, 2002.
88) Shimura T, Inoue M, Taga M, Shiraishi K, Uematsu N, Takei N, Yuan Z.M., Shinohara T, Niwa O : p53 Dependent S phase Damage Checkpoint and Pronuclear Crosstalk in Mouse Zygotes with X-Irradiated Sperm. Mol Cell Biol 22: 2220-8, 2002.
89) Kanzaki A, Toi M, Neamati N, Miyashita H, Oubu M, Nakayama K, Bando H, Ogawa K, Mutoh M, Mori S, Terada K, Sugiyama T, Fukumoto M, Takebayashi Y: Copper-transporting P-type adenosine triphosphatase. (ATP7B) is expressed in human breast carcinoma. Jpn J Cancer Res 93:70-7, 2002.
90) Kono K, Takahashi JA, Ueba T, Mori H, Hashimoto N, Fukumoto M: Effects of combination chemotherapy with biscoclaurine-derived alkaloid (Cepharanthine) and nimustine hydrochloride (ACNU) on malignant glioma cell lines. J Neurooncol 56:101-8, 2002.
91) Miyashita H, Takebayashi Y, Ellason JF, Fujimori F, Nitta Y, Sato A, Morikawa H, Ohashi A, Motegi K, Fukumoto M, Mori S, Uchida T: Uridine phosphorylase is a potent prognostic factor in patients with oral squamous cell carcinoma. Cancer 94: 2959-66 2002.
92) Goto A, Takebayashi Y, Liu D, Li L, Saiga T, Mori T, Yamadera A, Fukumoto M: Microdistribution of a-particles on pathological sections of Thorotrast patients detected by imaging plate autoradiography. Radiat Res 158:54-60, 2002.
93) Liu D, Li L, Ishikawa Y, Fukumoto M: Microsatellite instability in Thorotrast-induced human intrahepatic cholangiocarcinoma. Int J Cancer 102:366-71, 2002.
94) Kanzaki A, Takebayashi Y, Bando H, Eliason JF, Watanabe Si S, Miyashita H, Fukumoto M, Toi M, Uchida T. Expression of uridine and thymidine phosphorylase genes in human breast carcinoma. Int J Cancer 97:631-5, 2002.
95) Baba T, Iwasawa A, Yano T, Doi O, Suzuki F, Nakamura T: Estrogen in the chick embryo plays a role in utilization of plasma lipids during incubation. J Poultry Sci 39:77-83, 2002.
96) Baba T, Iwasawa A, Doi O, Suzuki F, Nakamura T: Correlating changes in follicular VLDL binding and follicular aromatase activity in the ovulation cycle of the laying hen. J Poultry Sci 39: 100-8, 2002.
97) Ishikawa Y, Wada I, Fukumoto M. Cancers induced by alpha-particles from Thorotrast. Ibid 191-4, 2002.
98) Nakayama K, Kanzaki A, Hata K, Katabuchi H, Okamura H, Miyazaki K, Fukumoto M, Takebayashi Y. Hypoxia-inducible factor 1 alpha (HIF-1 alpha) gene expression in human ovarian carcinoma. Cancer Lett 176:215-23, 2002.
99) Kondo S, Kuwahara Y, Kondo M, Naruse K, Mitani H, Wakamatsu Y, Ozato K, Asakawa S, Shimizu N, Shima A. The medaka rs-3 locus required for scale development encodes ectodysplasin-A receptor. Curr Biol 11:1202-6, 2001.
100) Masataka Taga, Kazunori Shiraishi, Tsutomu Shimura, Norio Uematsu, Tomohisa Kato, Yoshitake Nishimune, Shinichi Aizawa, Mitsuo Oshimura and Ohtsura Niwa : The Effect of Caffein on p53 Dependent Radioresponses in Undifferentiated Mouse Embryonal Carcinoma Cells after X-ray and UV-irradiations. J Radiation Res 2000, 41: 227-41
101) Masataka Taga, Kazunori Shiraishi, Tsutomu Shimura, Norio Uematsu, Mitsuo Oshimura and Ohtsura Niwa: Increased frequencies of gene and chromosome mutations after X-irradiation in mouse embryonal carcinoma cells transfected with the bcl-2 gene. Japanese Journal of Cancer Res 91: 994ー1000, 2000
102) Noriaki Shimizu, Tsutomu Shimura, Tsubasa Tanaka, Selective elimination of acetic double minutes from cancer cells through the extrusion of micronuclei, Mutation Res 448, 81-90,2000

英文総説

1) Fukumoto M, Kuwahara Y, Ohkubo Y, Wang L.: Analysis of carcinogenic mechanisms of liver cancers induced by chronic exposure to alpha-particles from internally deposited Thorotrast. Radiat Measure 41:1186-90, 2006.
2) Fukumoto M, Nakayama K: Ovarian epithelial tumors with low malignant potential (LMP): Are they precursors toward ovarian carcinoma? Pathol Int 56:233-239, 2006.
3) Fukumoto M, Kuwahara Y, Wang L, Liu D, Shimizu T, Wada I, Ishikawa Y, Mori T: Mechanisms of liver carcinogenesis in patients injected with Thorotrast. Health Effects of Incorporated Radionuclides GSF (Germany), pp239-242, 2005.
4) Ishikawa Y, Wada I, Fukumoto M: Alpha-particle carcinogenesis in Thorotrast patients: epidemiology, dosimetry, pathology and molecular analysis. J Environment Pathol Toxicol Oncol 20(4):311-5, 2001.
5) Fukumoto M, Takahashi JA, Murai N, Ueba T, Kono K, Nakatsu S: Induction of apoptosis in human glioma cells: an approach to control tumor growth by blocking basic fibroblast growth factor autocrine loop. Anticancer Res 20:4059-66, 2000.

日本語総説

1) 福本 学:東日本大震災.東日本大震災 1.病理研究者として被災して.病理と臨床.29(7):775-781, 2011.
2) 福本 学:放射線病理学:トロトラスト症から.病理と臨床.29(7):761-768, 2011.
3) 福本 学,桑原義和:放射線被ばくによる肝発がん:トロトラスト症発がん機構解明の温故知新.日本臨床.67(増刊3):156-60, 2009.
4) 桑原義和,馬場 泰輔,王 ル,村田 和浩,栗原 愛,海老島 茂子,山本 陽一郎,福本 学:放射線耐性を理解する上での問題点.放射線生物研究.41: 380-6, 2006.
5) 福本 学:分子病理学的にみた癌と境界悪性腫瘍. 病理と臨床. 24(2):167-72, 2006.
6) 福本 学:トロトラスト症、放射線発がん機構解明の温故知新.原安協だより.203:8-11, 2005.
7) 豊島めぐみ、志村勉、丹羽太貫 S期の制御機構 -p53依存性S期チェックポイントの発見-. 放射線生物研究.40: 325-38, 2005.
8) 福本 学, 松本康男:悪性腫瘍放射線治療後の二次癌:全国アンケート調査と症例解析.癌の臨床.50(13):1081-84, 2004.
9) 福本 学, 松本康男, 上羽哲也, 橋本信夫:放射線治療後の二次癌.放射線生物研究.38(4):421-35, 2003.
10) 福本 学: 分子生物学・免疫学 キーワード辞典(第二版) (永田和宏 他編), 医学書院(項目分担), 2003.
11) 福本 学: 臓器移植の病理:肺移植. 移植. 38(1):42-47, 2003.
12) 福本 学: 肺移植の病理. 病理と臨床. 19(6):627-33, 2001.

書籍

1) Fukumoto M, Kuwahara Y, Wang L, Liu D, Shimizu T, Wada I, Ishikawa Y, Mori T. Mechanisms of liver carcinogenesis in patients injected with Thorotrast. in Health Effects of Incorporated Radionuclides. GSF (Germany), pp.239-242, 2005.
2) Wang L, Liu D, Shimizu T, Wada I, Fukumoto M. Mechanisms of liver carcinogenesis by chronic exposure to alpha-particles form internally deposited Thorotrast. in High Levels of Natural Radiation and Radon Areas: Radiation Dose and Health Effects (International Congress Series 1276) (ed by Morishima et al.) (Excerpta Medica) pp192-194, 2005.
3) Liu D, Momoi H, Ishikawa Y, Fukumoto M: Genetic Instability in Thorotrast induced liver cancers. In Radiation and Homeostasis (International Congress Series 1236) (ed by Sugahara et al.) pp221-5 (Excerpta Medica) 2002.
4) Fukumoto M, Li L, Liu D, Suzuki M, Mori T, Tateno H, Wada I and Ishikawa Y: Present status of preservation and application of archival materials from Thorotrast patients. In Molecular Mechanisms for Radiation-Induced Cellular Response and Cancer Development. ( ed by K. Tanaka et al.) pp162-8, Inst for Env Res, Japan, 2002.
5) Fukumoto M, Midorikawa O: Analysis of c-myc amplification and expression in xenotransplanted human prostatic carcinoma cells. In Molecular Biology of Cancer Genes (ed by Sluyser M) pp193-206, Ellis Horwood Ltd, England, 1990.
6) 福本 学: 分子生物学・免疫学 キーワード辞典(第二版) (永田 和宏 他編), 医学書院(項目分担), 2003.

国際学会発表(シンポジウム、ワークショップ、セミナー等)

1) 志村勉、角田智 、落合泰史、野間直人、桑原義和、高井 良尋、福本学:AKT/GSK3beta/Cyclin D1/Cdk4経路を標的としたがん細胞の放射線耐性の抑制、 第17回 国際癌治療増感研究会、仙台、2011. 6
2) Manabu Fukumoto: Clinically relevant radioresistant cell efficiently repair DNA double-strand breaks induced by X-rays. 47th ISTC Japan Workshop, Nagasaki, 2008.12
3) Fukumoto M: Carcinogenic process of intrahepatic cholangiocarcinoma in comparison with hepatocellular carcinoma. Does molocular pathology have clinical relevance? 成功大医院病理部講演会, 台湾, 2006.3.
4) Imanaka T, Fukumoto M: Radiation dosimetry for the atomic bombings on Hiroshima and Nagasaki. International Conference Radioactivity after nuclear explosions and accidents, Moscow, 2005.12

国内学会発表(シンポジウム、ワークショップ、セミナー等)

1) 福本 学: 臨床的放射線耐性へのオートファジーの関与. 第99回日本病理学会総会, 東京, 2010.4
2) 栗原 愛、近藤 威、菓子野 元郎、小野 公二、篠原 邦夫、桑原 義和、福本 学: ラット正常脳へのマイクロビーム照射における病理組織学的解析. 第66回日本癌学会学術総会, 横浜, 2007.10
3) 福本 学: 分子病理学から見た卵巣境界悪性腫瘍. JSAWI 2008, 淡路, 2008.9
4) 福本 学: ヒト放射線内部被ばくによる肝発がんの分子機構:トロトラスト症から. 第40回日本臨床分子形態学会, 福岡, 2008.10
5) 桑原 義和、中川 浩伸、志村 勉、森 美由紀、栗原 愛、馬場 泰輔、福本 学: ラパマイシン投与による放射線耐性細胞への増感効果. 第67回日本癌学会, 名古屋, 2008.10
6) 堀江 佐知子、渡邊 夕紀子、陳 鋭、冨田 典子、大澤 ふき、小野 栄夫、福本 学、藤澤 優、松村 保広、森 士朗、小玉 哲也: 膀胱がん治療のための新しい薬剤到達法の開発. 第67回日本癌学会, 名古屋, 2008.10
7) 冨田 典子、堀江 佐知子、大澤 ふき、陳 鋭、渡邊 夕紀子、森川 秀広、大木 宏介、福本 学、森 士朗、小玉 哲也: 高周波超音波を利用した新しいリンパ節内微小管転移診断システムの開発. 第67回日本癌学会, 名古屋, 2008.10
8) 志村 勉、桑原 義和、福本 学、アラジャム ミリット: 複製フォーク進行阻害により誘導されるDNA2重鎖切断の生成機構とその修復. 日本放射線影響学会第51回大会, 北九州, 2008.11
9) 福本 学: 悪性腫瘍放射線治療後の二次癌. 第44回日本癌治療学会総会, 東京, 2006.10

受賞一覧

志村 勉:  平成22年度 放射線影響研究奨励賞 (財団法人 放射線影響協会)
平成22年度 日本放射線影響学会 奨励賞
桑原 義和:  日本放射線影響学会第54回大会 奨励賞

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