Last updatedF5/02/2015

ŸKimura T, Endo S, Inui M, Saitoh S-i, Miyake K, Takai T.
Endoplasmic protein Nogo-B (RTN4-B) interacts with GRAMD4 and regulates TLR9-mediated innate immune responses.
J. Immunol. 2015, April 27, doi:10.4049/jimmunol.1402006

ŸInui M, Tazawa K, Kishi Y, Takai T.
Platelets convert peripheral blood circulating monocytes to regulatory cells via immunoglobulin G and activating-type Fcgamma receptors.
BMC Immunology 2015, 16:20  doi:10.1186/s12865-015-0086-z
Published: 21 April 2015

ŸInui M*, Hirota S* (*equal contribution), Hirano K, Fujii H, Sugahara-Tobinai A, Ishii T, Harigae H, Takai T.
Human CD43+ B cells are closely related not only to memory B cells phenotypically but also to plasmablasts developmentally in healthy individuals.
Int Immunol. 2015 Mar 5. doi:10.1093/intimm/dxv009

ŸNehishi?Koga T, Gober HJ, Sumiya E, Komatsu N, Okamoto K, Sawa S, Suematsu S, Suda T, Sato K, Takai T, Takayanagi H.
Immune complexes regulate bone metabolism through FcRgamma signaling.
Nat Commun 2015 Mar 31;6:6637. doi: 10.1038/ncomms7637.

ŸKobayashi M, Konishi H, Takai T, Kiyama H.
A DAP12-Dependent Signal Promotes Pro-Inflammatory Polarization in Microglia Following Nerve Injury and Exacerbates Degeneration of Injured Neurons
Glia 2015 Jun;63(6):1073-82. doi: 10.1002/glia.22802. Epub 2015 Feb 17.

ŸKanno A, Tanimura N, Ishizaki M, Ohko K, Motoi Y, Onji M, Fukui R, Shimozato T, Yamamoto K, Shibata T, Sano S, Sugahara-Tobinai A, Takai T, Ohto U, Shimizu T, Saitoh S, Miyake K.
Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases.
Nat Commun 2015 Feb 4;6:6119. doi: 10.1038/ncomms7119.

ŸKanari Y, Sugahara?Tobinai A, Takahashi H, Inui M, Nakamura A, Hirose S, Takai T.
Dichotomy in the FcƒΑRIIB deficiency and autoimmune-prone SLAM haplotype clarifies the roles of the Fc receptor in development of autoantibodies and glomerulonephritis.
BMC Immunol 2014, 15:47@doi:10.1186/s12865-014-0047-y

ŸFukao S, Haniuda K, Nojima T, Takai T, Kitamura D.
gp49B-Mediated Negative Regulation of Antibody Production by Memory and Marginal Zone B Cells.
J Immunol. 2014 Jul 15;193(2):635-44. doi: 10.4049/jimmunol.1302772.

ŸYasukawa S, Miyazaki Y, Yoshii C, Nakaya M, Ozaki N, Toda S, Kuroda E, Ishibashi K, Yasuda T, Natsuaki Y, Mi-ichi F, Iizasa E, Nakahara T, Yamazaki M, Kabashima K, Iwakura Y, Takai T, Saito T, Kurosaki T, Malissen B, Ohno N, Furue M, Yoshida H, Hara H.
An ITAM-Syk-CARD9 signalling axis triggers contact hypersensitivity by stimulating IL-1 production in dendritic cells.
Nat Commun. 2014 May 7;5:3755. doi: 10.1038/ncomms4755.

ŸLo TH, Tseng KY, Tsao WS, Yang CY, Hsieh SL, Chiu AW, Takai T, Mak TW, Tarng DC, Chen NJ.
TREM-1 regulates macrophage polarization in ureteral obstruction.
Kidney Int. 2014 Jun 11. doi: 10.1038/ki.2014.205.

ŸKam TI, Song S, Gwon Y, Park H, Yan JJ, Im I, Choi JW, Choi TY, Kim J, Song DK, Takai T, Kim YC, Kim KS, Choi SY, Choi S, Klein WL, Yuan J, Jung YK.
FcgammaRIIb mediates amyloid-beta neurotoxicity and memory impairment in Alzheimer's disease.
J Clin Invest. 2013 Jul 1;123(7):2791-802. doi: 10.1172/JCI66827.

ŸTammaro A, Stroo I, Rampanelli E, Blank F, Butter LM, Claessen N, Takai T, Colonna M, Leemans JC, Florquin S, Dessing MC. Role of TREM1-DAP12 in renal inflammation during obstructive nephropathy.
PLoS One. 2013 Dec 16;8(12):e82498. doi: 10.1371/journal.pone.0082498. eCollection 2013.

ŸMontalvo V, Quigley L, Vistica BP, Boelte KC, Nugent LF, Takai T, McVicar DW, Gery I.
Environmental factors determine DAP12 deficiency to either enhance or suppress immunopathogenic processes.
Immunology 2013 Dec;140(4):475-82. doi: 10.1111/imm.12158.

ŸMatsumoto M, Sasaki Y, Yasuda K, Takai T, Muramatsu M, Yoshimoto T, Nakanishi K.
IgG and IgE Collaboratively Accelerate Expulsion of Strongyloides venezuelensis in a Primary Infection.
Infect. Immun., 81: 2518-27 (2013) doi: 10.1128/IAI.00285-13.

ŸKawano S, Lin Q, Amano H, Kaneko T, Nishikawa K, Tsurui H, Tada N, Nishimura H, Takai T, Shirai T, Takasaki Y, Hirose S.
Phenotype conversion from rheumatoid arthritis to systemic lupus erythematosus by introduction of Yaa mutation into FcƒΑRIIB-deficient C57BL/6 mice.
Eur J Immunol. 2013 Mar;43(3):770-8. doi: 10.1002/eji.201243057. Epub 2013 Jan 25.

ŸTanaka J, Hirano K, Sakamoto Y, Sugahara-Tobinai A, Endo S, Ito-Matsuoka Y, Nakano A, Inui M, Nitschke L, Takai T.
Intravenous immunoglobulin suppresses IL-10 production by activated B cells in vitro.
Open J. Immunol. 2(4): 149-160, 2012 (DOI: 10.4236/oji.2012.24019)

ŸKuroki K, Hiorse K, Okabe Y, Fukunaga Y, Takahashi A, Shiroishi M, Kajikawa M, Tabata S, Nakamura S, Takai T, Koyanagi S, Ohdo S, Maenaka K.
The long-term immunosuppressive effects of disulfide-linked HLA-G dimer in mice with collagen-induced arthritis.
Human Immunol. Dec. 29, 2012 (doi:pii: S0198-8859(12)00688-X.10.1016/j.humimm.2012.11.060)

ŸNakayama M, Kurokawa K, Nakamura K, Lee BL, Sekimizu K, Kubagawa H, Hiramatsu K, Yagita H, Okumura K, Takai T, Uderhill DM, Aderem A, Ogasawara K.
Inhibitory receptor PIR-B is exploited by Staphylococcus aureus for virulence.
J. Immunol.189: 5903-11, 2012. (doi: 10.4049/jimmunol.1201940)

ŸZangi L, Klionsky YZ, Yarimi L, Bacher-Lustig E, Edelshtein Y, Shezen E, Hagin D, Ito Y, Takai T, Reichi-Zeliger S, Lask A, Milstein O, Jung S, Shinder V, Reisner Y.
Deletion of cognate CD8 T-cells by immature dendritic cells: a novel role for perforin, Granzyme A, TREM-1 and TLR7.
Blood 120(8):1647-57, 2012 (doi: 10.1182/blood-2012-02-410803)

ŸWong WF, Kohu K, Nakamura A, Ebina M, Kikuchi T, Tazawa R, Tanaka K, Kon S, Funaki T, Sugahara-Tobinai A, Looi CY, Endo S, Funayama R, Kurokawa M, Habu S, Ishii N, Fkumoto M, Nakata K, Takai T, Satake M.
Runx1 deficiency in CD4+ T cells causes fatal autoimmune inflammatory lung disease due to spontaneous hyperactivation of cells.

J. Immunol. 2012; 188: 5408-5420; Epub 2 May 2012; doi: 10.4049/jimmunol.1102991

ŸMitsuhashi Y, Nakamura A, Endo S, Takeda K, Yabe-Wada T, Nukiwa T, Takai T.
Regulation of plasmacytoid dendritic cell responses by PIR-B
Blood 120: 3256-9, 2012, doi:10.1182/blood-2012-03-419093

ŸPresumptive role of 129 strain-derived Sle16 locus in rheumatoid arthritis in a new mouse model with Fcgamma receptor type IIb-deficient C57BL/6 genetic background.
Sato-Hayashizaki A, Ohtsuji M, Lin Q, Hou R, Ohtsuji N, Nishikawa K, Tsurui H, Sudo K, Ono M, Izui S, Shirai T, Takai T, Nishimura H, Hirose S.
Arthritis Rheum. 2011 Oct;63(10):2930-8. doi: 10.1002/art.30485.

ŸNatural killer (NK)-dendritic cell interactions generate MHC class II-dressed NK cells that regulate CD4+ T cells.
Nakayama M, Takeda K, Kawano M, Takai T, Ishii N, Ogasawara K.
Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18360-5. Epub 2011 Oct 31.

ŸControl of pathogenic CD4 T cells and lethal immunopathology by signaling immunoadaptor DAP12 during influenza infection.
McCormick S, Shaler CR, Small CL, Horvath C, Damjanovic D, Brown EG, Aoki N, Takai T, Xing Z.
J Immunol. 2011 Oct 15;187(8):4280-92. Epub 2011 Sep 9.

ŸThe p75 receptor mediates axon growth inhibition through an association with PIR-B.
Fujita Y, Takashima R, Endo S, Takai T, Yamashita T.
Cell Death Dis. 2011 Sep 1;2:e198. doi: 10.1038/cddis.2011.85.

ŸThe immunoreceptor adapter protein DAP12 suppresses B lymphocyte-driven adaptive immune responses.
Nakano-Yokomizo T, Tahara-Hanaoka S, Nakahashi-Oda C, Nabekura T, Tchao NK, Kadosaki M, Totsuka N, Kurita N, Nakamagoe K, Tamaoka A, Takai T, Yasui T, Kikutani H, Honda S, Shibuya K, Lanier LL, Shibuya A.
J Exp Med. 2011 Aug 1;208(8):1661-71. Epub 2011 Jul 4.

ŸMycobacterial hypersensitivity pneumonitis requires TLR9-MyD88 in lung CD11b+ CD11c+ cells.
Daito H, Kikuchi T, Sakakibara T, Gomi K, Damayanti T, Zaini J, Tode N, Kanehira M, Koyama S, Fujimura S, Ebina M, Ishii KJ, Akira S, Takai T, Watanabe A, Nukiwa T.
Eur Respir J. 2011 Sep;38(3):688-701. Epub 2011 Jan 27.

ŸMatsushita H, Endo S, Kobayashi E, Kobayashi K, Kitaguchi K, Kuroki K, Soderhall A, Maenaka K, Nakamura A, Takai T.
Differential but competitive binding of Nogo and MHCI to PIR-B provides an inhibition of cells.
J. Biol. Chem. 2011 Jul 22;286(29):25739-47. Epub 2011 Jun 2.

ŸArita K, Endo S, Kaifu T, Kitaguchi K, Nakamura A, Ohmori H, Kohu K, Satake M, Takai T.
Transcriptional activation of the Pirb gene in B cells by PU.1 and Runx3.
J. Immunol. Jun 15; 186(12): 7050-7059. Epub 2011 May 9

ŸMa G, Pan PY, Eisenstein S, Divino CM, Lowell C, Takai T, Chen SH:
Paired immunoglobulin like receptor-B regulates the suppressive function and fate of myeloid derived suppressor cells
Immunity 34: 385-395, 2011.

ŸFujita Y, Endo S, Takai T, Yamashita T.
Myelin suppresses axon regeneration by PIR-B/SHP-mediated inhibition of Trk activity.
EMBO J. 2011 Apr 6;30(7):1389-401. Epub 2011 Mar 1.

ŸNakamura, Y., Fujita, Y., Ueno, M., Takai, T. and Yamashita, T.
Paired immunoglobulin-like receptor B knockout does not enhance axonal regeneration or locomotor recovery after spinal cord injury.
J. Biol. Chem. 2011, Jan 21; 286(3):1876-83. Epub 2010 Nov 18.

ŸTakai T, Nakamura A, Endo S.
Role of PIR-B in Autoimmune Glomerulonephritis.
J. Biomed. Biotech. vol. 2011: 275302, 2010. doi:10.1155.2011.275302

ŸOmoto S, Ueno M, Mochio S, Takai T, Yamashita T.
Genetic deletion of paired immunoglobulin-like receptor B does not promote axonal plasticity or functional recovery after traumatic brain injury.
J. Neurosci. 30: 13045-13052, 2010.

ŸYamamoto M, Kobayashi K, Ishikawa Y, Nakata K, Funada Y, Kotani Y, Masuda A, Takai T, Azuma T, Yoshida M, Nishimura Y.
The inhibitory effects of intravenous administration of rabbit IgG on airway inflammation are dependent on Fcgamma receptor IIb on CD11c+ dendritic cells in murine model.
Clin. Exp. Immunol. 2010 Nov; 162(2):315-24. doi: 10.1111/j.1365-2249.2010.04243.x. Epub 2010 Sep 1.

ŸYamanishi Y, Kitaura J, Izawa K, Kaitani A, Komeno Y, Nakamura M, Yamazaki S, Enomoto Y, Oki T, Akiba H, Abe T, Komori T, Morikawa Y, Kiyonari H, Takai T, Okumura K, Kitamura T.
TIM1 is an endogenous ligand for LMIR5/CD300b: LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury.
J. Exp. Med. 2010 Jul 5;207(7):1501-11. Epub 2010 Jun 21.

ŸTakai T, Karasuyama H
(Review) The study of allergy by Japanese researchers: a historical perspective.
Int. Immu. 21(12):1311-6, 2009. Epub 2009 Oct 25. [Epub ahead of print]

ŸKubo T, Uchida Y, Watanabe Y, Abe M, Nakamura A, Ono M, Akira S, Takai T
Augmented TLR9-induced Btk activation in PIR-B-deficient B-1 cells provokes excessive autoantibody production and autoimmunity.
J. Exp. Med. 206(9):1971-82, 2009. Epub Online 17 August 2009.

ŸImada M, Masuda M, Satoh R, Ito Y, Goto Y, Matsuoka T, Endo S, Nakamura A, Kawamoto H, Takai T: Ectopically expressed PIR-B on T cells constitutively binds to MHC class I and attenuates T helper type 1 responses.
Int. Immu. Online publication on Aug. 14, 2009. Oct;21(10):1151-61. Epub 2009 Aug 14.

ŸOtero K, Turnbull IR, Poliani L, Vermi W, Aoshi T, Takai T, Stanley SL, Miller M, Colonna M. MCSF induces macrophage proliferatin and survival through a DAP12-beta-catenin signaling pathway.
Nat. Immunol. 10: 734-743 (2009) Epub 2009 Jun 7.

ŸOrr MT, Sun JC, Arase H, Phillips JH, Takai T, Lanier LL. DAP12-independent Ly49H-mediated NK cell responses against mouse cytomegalovirus.
J. Exp. Med. 206: 807-817 (2009) Epub 2009 Mar 30.

ŸLi L, Kaifu T, Obinata M, Takai T. Peroxiredoxin III-deficiency sensitizes macrophages to oxidative stress.
J. Biochem. 2009 Apr;145(4):425-427.

ŸInui M, Kikuchi Y, Aoki N, Endo S, Maeda T, Sugahara-Tobinai A, Nakamura A, Kumanogoh A, Colonna M, Takai T. Signal adaptor DAP10 associates with MDL-1 and triggers osteoclastogenesis in cooperation with DAP12.
Proc Natl Acad Sci USA. 2009 Feb 27. [Epub ahead of print] 106 (12): 4816-4821 (2009)

ŸTassi I, Le Friec G, Gilfillan S, Takai T, Yokoyama WM, Colonna M. DAP10 associates with Ly49 receptors but contributes minimally to their expression and function in vivo.
Eur. J. Immunol. 2009 Feb 26;39(4):1129|1135.

ŸHelming L, Tomasello E, Kyriakides TR, Martinez FO, Takai T, Gordon S, Vivier E. Essential role of DAP12 signaling in macrophage programming into a fusion-competent state.
Sci Signal. 2008 Oct 28;1(43):ra11.

ŸHida S, Yamasaki S, Sakamoto Y, Takamoto M, Obata K, Takai T, Karasuyama H, Sugane K, Saito T, Taki S. Fc receptor g-chain, a constitutive component of the interleukin-3 receptor, is required for interleukin 3-induced interleukin 4 production in basophils.
Nat. Immunol. 2009 Feb;10(2):214-222. Epub 2008 Dec 21.

ŸEndo S, Sakamoto Y, Nakamura A, Takai T. Regulation of cytotoxic T lymphocyte triggering by PIR-B on dendritic cells.
Proc. Natl. Acad. Sci. USA 105: 14515-14520 (2008)

ŸMori Y, Tsuji S, Inui M, Sakamoto Y, Endo S, Ito Y, Fujimura S, Koga T, Nakamura A, Takayanagi H, Itoi E, Takai T. Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development.
J. Immunol. 181 (7): 4742-4751 (2008)

ŸTorii I, Oka S, Hotomi M, Benjamin WH Jr, Takai T, Kearney JF, Briles DE, Kubagawa H. PIR-B-deficient mice are susceptible to Salmonella infection.
J. Immunol. 181(6):  4229-4239 (2008)

ŸKasai S, Inui M, Nakamura K, Kakizaki Y, Endo S, Nakamura A, Ito S, Takai T. A novel regulatory role of gp49B on dendritic cells in T cell priming.
Eur. J. Immunol. 38: 2426-2437 (2008)

ŸKofu K, Yamabe E, Matsuzawa A, Onda D, Suemizu H, Sasaki E, Tanioka Y, Yagita H, Suzuki D, Kametani Y, Takai T, Toyoda A, Habu S, Satake M. Comparison of 30 immunity-related genes from thecommon marmoset with orthologues from human and mouse.
Tohoku J. Exp. Med. 215: 167-180 (2008)

ŸMasuda A, Yoshida M, Shiomi H, Ikezawa S, Takagawa T, Tanaka H, Chinzei R, Ishida T, Morita Y, Kutsumi H, Inokuchi H, Wang S, Kobayashi K, Mizuno S, Nakamura A, Takai T, Blumberg RS, Azuma T.
Fcgamma Receptor Regulation of Citrobacter rodentium Infection.
Infect. Immunity 76: 1728-1737 (2008)

Shinohara M, Koga T, Okamoto K, Sakaguchi S, Arai K, Yasuda H, Takai T, Kodama T, Morio T, Geha RS, Kitamura D, Kurosaki T, Ellmeier W, Takayanagi H.
Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals.
Cell 132(5):794-806 (2008)

Yamanishi Y, Kitaura J, Izawa K, Matsuoka T, Oki T, Lu Y, Shibata F, Yamazaki S, Kumagai H, Nakajima H, Maeda-Yamamoto M, Tybulewicz VLJ, Takai T, Kitamura T. Analysis of mouse LMIR5/CLM7 as an activating receptor: differential regulation of LMIR5/CLM7 in ouse versus human cells.
Blood 111: 688-698 (2008)

Giurisato E, Cella M, Takai T, Kurosaki T, Feng Y, Longmore GD, Colonna M, Shaw AS.
PI3-kinase activation is required to form the NKG2D immunological synapse.
Mol Cell Biol. 27: 8583-8599 (2007)

ŸKojima T, Obata K, Muikai K, Sato S, Takai T, Minegishi Y, Karasuyama H.
A CD200 receptor-like protein CD200R3 functions as an activating receptor expressed exclusively on basophils and mast cells.
J. Immunol. 179: 7093-7100 (2007)

ŸDivangahi M, Yang T, Kugathasan K, McCormick S, Takenaka S, Gaschler G, Ashkar A, StampfliM, Gauldie J, Bramson J, Takai T, Brown E, Yokoyama WM, Aoki N and Xing Z.
Critical Negative Regulation of type 1 T cell immunity and immunopathology by signaling adaptor DAP12 during intracellular infection.
J. Immunol. 179: 4015-4026 2007)

ŸInoue Y, Kaifu T, SugaharaΠTobinai A, Nakamura A, Miyazaki J-I, Takai T.
Activating Fcgamma receptors participate in the development of autoimmune diabetes in NOD mice.
J. Immunol. 179(2): 764-774 (2007)

ŸOchi S, Shinohara M, Sato K, Gober H-J, Koga T, Kodama T, Takai T, Miyasaka N, Takayanagi H.
Pathological role of osteoclast costimulation in arthritis-induced bone loss.
Proc. Natl. Acad. Sci. USA 104(27): 11394-11399 (2007)

ŸHara H, Ishihara C, Takeuchi A, Xue L, Morris SW, Imanishi T, Inui M, Takai T, Shibuya A, Koseki H, Yoshida H, Penninger JM, Saito T.
The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors.
Nat. Immunol. 8: 619-629 (2007)

Masuda A*, Nakamura A* (*equal contributor), Maeda T, Sakamoto Y, Takai, T.
Cis binding between inhibitory receptors and MHC class I can regulate mast cell activation.
J. Exp. Med. 204: 907-920 (2007)

Izawa K, Kitaura J, Yamanishi Y, Matsuoka T, Oki T, Shibata F, Kumagai H, Nakajima H, Maeda-Yamamoto M, Hauchins JP, Tybulewicz VL, Takai T, Kitamura T.
Functional analysis of an activating receptor LMIR4 as a counterpart of an inhibitory receptor LMIR3.
J Biol Chem. 282: 17997-18008 (2007)

Li L, Shoji W, Takano H, Nishimura N, Aoki Y, Takahashi R, Goto S, Kaifu T, Takai T, Obinata M.
Increased susceptibility of MER5 (peroxiredoxin III) knockout mice to LPS-induced oxidative stress.
Biochem. Biophys. Res. Commun. 355(3): 715-721 (2007)

Nakayama M, Underhill DM, Petersen TW, Li B, Kitamura T, Takai T, Aderem A.
Paired Ig-like receptors bind to bacteria and shape TLR-mediated cytokine production.
J. Immunol. 178(7):4250-4259 (2007)

Nakahashi C, Tahara-Hanaoka S, Totsuka N, Okoshi Y, Takai T, Ohkochi N, Honda S-i, Shibuya K, Shibuya A.
Dual assemblies of an activating immune receptor, MAIR-II, with ITAM-bearing adaptors DAP12 and FcRƒΑ chain on peritoneal macrophages.
J. Immunol. 178(2): 765-770 (2007)

Sato K, Suematsu A, Nakashima T, Takemoto-Kimura S, Aoki K, Morishita Y, Asahara H, Ohya K, Yamaguchi A, Takai T, Kodama T, Chatila TA, Bito H, Takayanagi H.
Regulation of osteoclast differentiation and function by the CaMK/CREB pathway.
Nat. Med. 12(12):1410-1416 (2007)

Kitamura K*, Takeda K*, Koya T*, Miyahara N* (*equal contributors), Kodama T, Dakhama A, Takai T, Hirano A, Tanimoto M, Harada M, Gelfand EW.
Critical role of the Fc receptor ƒΑ-chain on APCs in the development of allergen-induced airway hyperresponsiveness and inflammation.
J. Immunol. 178(1):480-488 (2007)

ŸGraham DB, Cella M, Giurisato E, Fujikawa K, Miletic AV, Kloeppe T, Brim K, Takai T, Shaw AS, Colonna M and Swat W.
Vav1 controls NKG2D-DAP10-mediated NK cell cytoskeletal remodeling and natural cytotoxicity.
J. Immunol.
177 (4): 2349-2355 (2006).

ŸIizuka S, Kaifu T, Nakamura A, Obinata M, Takai T.
Establishment and functional characterization of novel natural killer cell lines derived from a temperature-sensitive SV40 large T antigen transgenic mouse.
J. Biochem. (Tokyo)
140 (2): 255-265 (2006).

ŸKanehira M, Kaifu T, Maya K, Kaji M, Nakamura A, Obinata M, Takai T.
Novel mast cell lines with enhanced proliferative and degranulative abilities established from temperature-sensitive SV40 large T antigen transgenic mice.
J. Biochem. (Tokyo)
140 (2): 211-220 (2006).

ŸTakegahara N, Takamatsu H, Toyofuku T, Tsujimura T, Okuno T, Yukawa K, Mizui M, Yamamoto M, Prasad DV, Suzuki K, Ishii M, Terai K, Moriya M, Nakatsuji Y, Sakoda S, Sato S, Akira S, Takeda K, Inui M, Takai T, Ikawa M, Okabe M, Kumanogoh A, Kikutani H.
Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis.
Nat. Cell. Biol. 8 (6): 615-622 (2006).

ŸBlasius AL, Cella M, Maldonado J, Takai T, Colonna M.
Siglec-H is an IPC-specific receptor that modulates type I IFN seecretion through DAP12.
107(6):2474-2476 (2006).

ŸOkazaki T, Otaka Y, Wang J, Hiai H, Takai T, Ravetch JV, and Honjo T.
Hydronephrosis associated with anti-urothelial and anti-nuclear autoantibodies in BALB/c-Fcgr2b-/-Pdcd1-/- mice.
J. Exp. Med.
202: 1643-1648 (2005).

ŸTakai T.
A novel recognition system for MHC class I molecules constituted by PIR.
Adv. Immunol.
(Review) 88: 161-192 (2005).

ŸTurnbull IR, McDunn JE, Takai T, Townsend RR, Cobb JP, Colonna M.
DAP12 (KARAP) amplifies inflammation and increases mortality from endotoxemia and septic peritonitis.
J. Exp. Med.
202(3):363-369 (2005)

ŸTakai T.
Paired Immunoglobulin-like Receptors and their MHC class I recognition.
(Review) 115(4):433-440 (2005).

ŸXie X, He H, Colonna M, Seya T, Takai T, Croy BA.
Pathways participating in activation of mouse uterine natural killer cells during pregnancy.
Biol Reprod
73: 510-518 (2005)

ŸZhang H, Meng F, Chu C-L, Takai T, Lowell C.
The src-family kinases Hck and Fgr negatively regulate neutrophil and dendritic cell chemokine signaling via PIR-B.
22, 235-246 (2005).

ŸTakai T.
Fc receptors and their role in immune regulation and autoimmunity.
J. Clin. Immunol.
(Review) 25: 1-18 (2005).

ŸNakamura A, Akiyama K, Takai T.
Fc receptor targeting in the treatment of allergy, autoimmune diseases and cancer.
Expert Opinion on Therapeutic Targets
(Review) 9(1):169-190 (2005).

ŸPereira S, Zhang H, Takai T, Lowell CA.
The inhibitory receptor PIR-B negatively regulates neutrophil and macrophage integrin signaling.
J. Immunol.
173(9): 5757-5765 (2004)@reprint (pdf) of this article is available upon request to

ŸEbihara S, Endo S, Ito K, Ito Y, Akiyama K, Obinata M, Takai T.
Immortalized dendritic cell line with efficient cross-priming ability established from transgenic mice harboring the temperature-sensitive SV40 large T-antigen gene.
J. Biochem.
136: 321-328 (2004)@reprint (pdf) of this article is available upon request to

ŸNakamura A, Kobayashi E, Takai T.
Exacerbated graft-versus-host disease in Pirb-/- mice.
Nature Immunol.
5 (6): 623 - 629 (2004). Published online: 16 May 2004 | doi:10.1038/ni1074 [PUBMED ABSTRACT]@reprint (pdf) of this article is available upon request to

ŸKoga T,* Inui M,* Inoue K, Kim S, Suematsu A, Kobayashi E, Iwata T, Ohnishi H, Matozaki T, Kodama T, Taniguchi T, Takayanagi H, Takai T (*equal contributor)
Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis.
428: 758-763 (2004). [PUBMED ABSTRACT]@reprint (pdf file) of this article is available upon request to

ŸYamaguchi, A., Katsuyama, K., Nagahama, K., Takai, T., Aoki, I., Yamanaka, S.
Possible role of autoantibody in the pathophysiology of GM2 angliosidoses.
J. Clin. Invest.
113: 200-208 (2004). [PUBMED ABSTRACT] reprint (pdf) of this article is available upon request to

ŸWatanabe, T., Okano, M., Hattori, H., Yoshino, T., Ohno, N., Ohta, N., Sugata, Y., Orita, Y., Takai, T., Nishizaki, K.
Roles of FcƒΑRIIB in nasal eosinophilia and IgE production in murine allergic rhinitis.
Am. J. Respir. Crit. Care Med.
169: 105-112 (2004) (Epub ahead of print, Oct. 2, 2003) [PUBMED ABSTRACT] reprint (pdf) of this article is available upon request to

ŸYada, A., Ebihara, S., Matsumura, K., Akiyama, K., Aiba, S., and Takai, T.
Contribution of FcƒΑ receptors to antigen presentation and elicitation of humoral response in vivo.
Cell. Immunol.
225(1):21-32 (2003). [PUBMED ABSTRACT] reprint (pdf) of this article is available upon request to

ŸNakahara, J., Tan-Takeuchi, K., Seiwa, C, Gotoh, M., Kaifu, T., Ujike, A., Inui, M., Yagi, T., Aiso, S., Takai, T., and Asou, H.
Signaling via immunoglobulin Fc receptors induces oligodendrocyte precursor cell differentiation.
Dev. Cell
4(6): 841-852 (2003). [PUBMED ABSTRACT]

ŸNakamura, A., Nukiwa, T., Takai, T.
Deregulation of peripheral B cell development in enhanced severity of collagen-induced arthritis in FcƒΑRIIB-deficient mice.
J. Autoimmu.
20:227-236 (2003). [PUBMED ABSTRACT]

ŸTakai, T., Nakamura, A., Akiyama, K.
Fc receptors as potential targets for treatment of allergy, autoimmune disease and cancer.
Current Drug Targets-Immune, Endocrine & Metabolic Disorders.
(Review) 3: 187-197 (2003) [PUBMED ABSTRACT] reprint (pdf) of this article is available upon request to

ŸNakamura, A., Mori, Y., Hagiwara, K., Suzuki, T., Sakakibara, T., Kikuchi, T., Igarashi, T., Ebina, M., Miyazaki, J., Takai, T., Nukiwa, T.
Increased susceptibility to LPS-induced endotoxin shock in secretory leukoprotease inhibitor (SLPI)-deficient mice.
J. Exp. Med.
197: 669-674 (2003) [PUBMED ABSTRACT]

ŸYajima K, Nakamura A, Sugahara A, Takai T.
FcgRIIB deficiency with Fas mutation is sufficient for the development of systemic autoimmune disease.
Eur. J. Immunol.
33: 1020-1029 (2003) [PUBMED ABSTRACT]

ŸTaube C, Takeda K, Dakhama A, Rha Y, Joetham A, Park J.-W, Ballhorn A, Takai T, Benchich KR, Nick JA, Gelfand EW.
Transient neutrophil inflammation after allergen challenge is dependent on specific antibodies and Fc receptors.
J. Immunol.
170: 4301-4309 (2003) [PUBMED ABSTRACT]

ŸNieswandt, B., Bergmeier, W., Schulte, V., Takai, T., Baumann, U., Schmidt, R.E., Zirngibl, H., Bloch, W. and Gessner, J.E.
Targeting of platelet integrin ƒΏIIbƒΐ3 determines systemic reaction and bleeding in murine thrombocytopenia regulated by activating and inhibitory FcgRs
Int. Immunol. 15: 341-349 (2003) [PUBMED ABSTRACT]

ŸAkiyama K, Ebihara S, Yada, A., Matsumura, K., Aiba, S., Nukiwa, T., and Takai T.
Targeting of apoptotic tumor cells to FcƒΑ receptors provides efficient and versatile vaccination against tumors by dendritic cells.
J. Immunol.
170 (4): 1641-1648 (2003) [PUBMED ABSTRACT]

Ÿ Kaifu, T.*, Nakahara, J.*, Inui, M.*, Mishima, K., Momiyama, T., Kaji, M., Sugahara, A., Koito, H., Ujike-Asai, A., Nakamura, A., Kanazawa, K., Tan-Takeuchi, K., Iwasaki, K., Yokoyama, W.M., Kudo, A., Fujiwara, M., Asou, H., and Takai, T. (*equal contributor)
Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice.
J. Clin. Invest.
111 (3): 323-332 (2003) [PUBMED ABSTRACT]

Ÿ Takai T.
Roles of Fc receptors in autoimmunity.
Nature Rev. Immunol. 2, 580-592 (2002).[PUBMED ]
[PDF file is available upon request to T. Takai at:]

Ÿ Ujike, A., Takeda, K., Nakamura, A., Ebihara, S., Akiyama, K. & Takai, T.
Impaired dendritic cell maturation and increased TH2 responses in PIR-B-/- mice.
Nature Immunol. 3, 542-548 (2002).[PUBMED ABSTRACT]

Ÿ Makabe-Kobayashi Y, Hori Y, Adachi T, Ishigaki-Suzuki S, Kikuchi Y, Kagaya Y, Shirato K, Nagy A, Ujike A, Takai T, Watanabe T, and Ohtsu H.
The control effect of histamine on the body temperature and respiratory function in IgE-dependent systemic anaphylaxis.
J. Allergy Clin. Immunol. 110, 298|303 (2002).[PUBMED ABSTRACT]

Ÿ Kato I, Takai T, and Kudo A.
The pre-B cell receptor signaling for apoptosis is negatively regulated by FcgRIIB.
J. Immunol. 168: 629|634 (2002). [PUBMED ABSTRACT]

Ÿ Yuasa, T., Ono, M., Watanabe, T., and Takai, T.
Lyn is essential for FcƒΑ receptor III-mediated systemic anaphylaxis but not for the Arthus reaction.
J. Exp. Med. 193: 563-572 (2001). [PUBMED ABSTRACT]

Ÿ Ono, M., Takai, T.
Function of gp49A in mast cell activation.
In: (M.D. Cooper, T. Takai, J.V. Ravetch eds)Activating and Inhibitory Immunoglobulin-Like Receptors. pp. 99-106, Springer-Verlag Tokyo, 2001.

Ÿ Takai, T., Nakamura, A.
Autoimmune arthritis and Goodpasture's syndrome induced in Fcg receptor-deficient mice. In: (M.D. Cooper, T. Takai, J.V. Ravetch eds) Activating and Inhibitory Immunoglobulin-Like Receptors. pp. 189-198, Springer-Verlag Tokyo, 2001.

Ÿ M. D. Cooper, T. Takai, J. V. Ravetch (Ed.)
Activating and Inhibitory Immunoglobulin-Like Receptors. Springer-Verlag Tokyo, 2001.

Ÿ Takai, T., and Ono, M. Activating and inhibitory nature of the murine paired Ig-like receptor (PIR) family.
Immunol. Rev. 181:215-22 (2001).[PUBMED ABSTRACT]

Ÿ Kaji, K., Takeshita, S., Miyake, K., Takai, T., and Kudo, A.
Functional association of CD9 molecule with FcƒΑIII receptor in macrophages.
J. Immunol. 166(5): 3256-3265 (2001). [PUBMED ABSTRACT]

Ÿ Yoneto, T., Waki, S., Takai, T., Tagawa, Y., Iwakura, Y., Mizuguchi, J., Nariuchi, H., and Yoshimoto, T.
A critical role of Fc receptor-mediated antibody-dependent phagocytosis in the host resistance to blood-stage Plasmodium berghei XAT infection.
J. Immunol.166(10):6236-6241 (2001). [PUBMED ABSTRACT]

Ÿ Lee, K.H., Ono, M., Inui, M., Yuasa, T., and Takai, T.
Stimulatory function of gp49A, a murine Ig-like receptor, in RBL-2H3 cells.
J. Immunol. 165(9):4970-4977 (2000). [PUBMED ABSTRACT]

Ÿ Onah DN, Uchiyama F, Nagakui Y, Ono M, Takai T, Nawa Y.
Mucosal defence against gastrointestinal nematodes: Responses of mucosal mast cells and mouse mast cell protease 1 during primary Strongyloides venezuelensis infection in FcRƒΑ-knockout mice.
Infect. Immun. 68(9): 4968-4971 (2000). [PUBMED ABSTRACT]

Ÿ Wakayama, H., Hasegawa, Y., Kawabe, T., Hara, T., Matsuo, S., Mizuno, M., Takai,T., Kikutani, H., Shimokata, K.
Abolition of anti-glomerular basement membrane antibody-mediated glomerulonephritis in FcRƒΑ-deficient mice.
Eur. J. Immunol. 30(4):1182-1190. (2000) [PUBMED ABSTRACT]

Ÿ Schiller, C., Janssen-Graalfs, I., Baumann, U., Schwerter-Strumpf, K., Izui, S., Takai, T., Schmidt, R.E., and Gessner, J.E.
Mouse FcƒΑRII is a negative regulator of FcƒΑRIII in IgG immune complex triggered inflammation but not in autoantibody induced hemolysis.
Eur. J. Immunol. 30:481-490 (2000). [PUBMED ABSTRACT]

Ÿ Nakamura, A., Yuasa, T., Ujike, A., Ono, M., Nukiwa, T., Ravetch, J.V., Takai, T.
FcƒΑ receptor IIB-deficient mice develop Goodpasture's syndrome upon immunization with type IV collagen: A novel murine model for autoimmune glomerular basement membrane disease.
J. Exp. Med. 191(5):899-906 (2000). [PUBMED ABSTRACT]

Ÿ Cortegano, I., del Pozo, V., C rdaba, B., Arrieta, I., Gallardo, S., Rojo, M., Aceituno, E., Takai, T., Verbeek, S., Palomino, P., Liu, F.-T., and Lahoz, C.
Interaction between galectin-3 and FcƒΑRII induces down-regulation of IL-5 gene: Implication of the promoter sequence IL-5REIII.
Glycobiol. 10(3):237-242 (2000). [PUBMED ABSTRACT]

Ÿ Ujike, A., Ishikawa, Y., Ono, M., Yuasa, T., Yoshino, T., Fukumoto, M., Ravetch, J. V., and Takai, T.
Modulation of IgE-mediated systemic anaphylaxis by low affinity Fc receptors for IgG.
J. Exp. Med. 189: 1573-1579 (1999). [PUBMED ABSTRACT]

Ÿ Yuasa, T., Kubo, S., Yoshino, T., Ujike, A., Matsumura, K., Ono, M., Ravetch, J.V., and Takai, T. Deletion of FcgRIIB renders H-2b mice susceptible to collagen-induced arthritis.
J. Exp. Med. 189: 187-194 (1999). [PUBMED ABSTRACT]

Ÿ Clynes, R., Maizes, J.S., Guinamard, R., Ono, M., Takai, T., and Ravetch, J.V.
Modulation of immune complex induced inflammation in vivo by the coordinate expression of activation and inhibitory Fc receptors.
J. Exp. Med. 189: 179-186 (1999). [PUBMED ABSTRACT]

Ÿ Ono, M., Yuasa, T., Ra, C., and Takai, T.
Stimulatory function of paired immunoglobulin-like receptor-A (PIR-A) in mast cell line by associating with subunits common to Fc receptors.
J. Biol. Chem. 274: 30288-30296 (1999). [PUBMED ABSTRACT]

Ÿ Takai, T., Ono, M., Ujike, A., and Yuasa, T.
Regulation of murine hypersensitive responses by Fc receptors.
Allergol. Intern. 47: 75-83 (1998).

Ÿ Takai, T., and Ravetch, J.V.
Fc receptor genetics and the manipulation of genes in the study of FcR biology.
In: Immunoglobulin Receptors and their Physiological and Pathological Roles in Immunity, Eds J. G. J. van de Winkel and P. Mark Hogarth, Kluwer Academic Publishers, Netherland, pp. 37-48, 1998.

Ÿ Yamashita, Y., Ono, M., and Takai, T.
Inhibitory and stimulatory functions of the paired immunoglobulin-like receptor (PIR) family in RBL-2H3 cells.
J. Immunol. 161: 4042-4047 (1998). [PUBMED ABSTRACT]

Ÿ Suzuki Y, Shirato I, Okumura K, Ravetch JV, Takai T, Tomino Y, Ra C.
Distinct contribution of Fc receptors and angiotensin II-dependent pathways in anti-GBM glomerulonephritis.
Kidney Int. 54: 1166-1174 (1998) . [PUBMED ABSTRACT]

Ÿ Maeda, A., Kurosaki, M., Ono, M., Takai, T., and Kurosaki, T.
Requirement of SH2-containing protein tyrosine phosphatases SHP-1 and SHP-2 for paired immunoglobulin-like receptor B (PIR-B)-mediated inhibitory signal.
J. Exp. Med. 187: 1355-1360 (1998). [PUBMED ABSTRACT]

Ÿ Watanabe, N., Nomura, T., Takai, T., Chiba, T., Honjo, T., and Tsubata, T.
Antigen receptor cross-linking by anti-immunoglobulin antibodies coupled to cell surface membrane induces rapid apoptosis of normal spleen B cells.
Scand. J. Immunol. 47, 541-547 (1998). [PUBMED ABSTRACT]

Ÿ Yamashita, Y., Fukuta, D., Tsuji, A., Nagabukuro, A., Matsuda, Y., Nishikawa, Y., Ohyama, Y., Ohmori, H., Ono, M., and Takai, T.
Genomic structures and chromosomal location of p91, a novel murine regulatory receptor family.
J. Biochem. 123, 358-368 (1998). [PUBMED ABSTRACT]

Ÿ Kuroiwa, A., Yamashita, Y., Inui, M., Yuasa, T., Ono, M., Nagabukuro, A., Matsuda, Y., and Takai, T.
Association of tyrosine phosphatases SHP-1 and SHP-2, and inositol 5-phosphatase SHIP with gp49B1, and chromosomal assignment of the gene.
J. Biol. Chem. 273, 1070-1074 (1998). [PUBMED ABSTRACT]

Ÿ Takai T, Yamashita Y, Nishikawa Y, Fukuta D, Ohyama Y, Inui M, Hikida M, Ohmori H, Ono M.
p91, a novel murine KIR-like molecule expressed on macrophages and mast cells.
In: Kinases and Phosphatases in Lymphocyte and Neuronal Signaling. (ed. Yakura H), pp. 359-360, Springer-Verlag, Tokyo, 1997.

Ÿ Hayami, K., Fukuta, D., Nishikawa, Y., Yamashita, Y., Inui, M., Ohyama, Y., Hikida, M., Ohmori, H., and Takai, T.
Molecular cloning of a novel murine cell-surface glycoprotein homologous to killer cell inhibitory receptors.
J. Biol. Chem. 272, 7320-7327 (1997). [PUBMED ABSTRACT]

Ÿ Takai, T.
Multiple loss of effector cell functions in FcRg-deficient mice.
Intern. Rev. Immunol. 13, 369-381 (1996) . [PUBMED ABSTRACT]

Ÿ Takai, T., Ono, M., Hikida, M., Ohmori, H., and Ravetch, J. V.
Augmented humoral and anaphylactic responses in FcgRII-deficient mice.
Nature 379, 346-349 (1996). [PUBMED ABSTRACT]