田中耕三 研究室 Department of Molecular Oncology-Publications



Original articles(2004~)

  • Chen G, Li Z, Iemura K, Tanaka K. Oxidative stress induces chromosomal instability through replication stress in fibroblasts from aged mice. J Cell Sci (2023) 136, jcs260688. [PubMed]
  • Irikura R, Nishizawa H, Nakajima K, Yamanaka M, Chen G, Tanaka K, Onodera M, Matsumoto M, Igarashi K. Ferroptosis model system by the re-expression of BACH1. J Biochem (2023) mvad036. [PubMed]
  • Shindo N, Kumada K, Iemura K, Yasuda J, Fujimori H, Mochizuki M, Tamai K, Tanaka K, Hirota T. Autocleavage of separase suppresses its premature activation by promoting binding to cyclin B1. Cell Rep (2022) 41, 111723. [PubMed]
  • Nagai M, Iemura K, Kikkawa T, Naher S, Hattori S, Hagihara H, Nagata K, Anzawa H, Kugisaki R, Wanibuchi H, Abe T, Inoue K, Kinoshita K, Miyakawa T, Osumi N, Tanaka K. Deficiency of CHAMP1, a gene related to intellectual disability, causes impaired neuronal development and a mild behavioral phenotype. Brain Commun (2022) 4, fcac220. [PubMed]
  • Iemura K, Anzawa H, Funayama R, Iwakami R, Nakayama K, Kinoshita K, Tanaka K. High levels of chromosomal instability facilitate the tumor growth and sphere formation. Cancer Sci (2022) 113, 2727-2737. [PubMed]
  • Fujita H, Ikeda M, Ui A, Ouchi Y, Mikami Y, Kanno S, Yasui A, Tanaka K. CHAMP1-POGZ counteracts the inhibitory effect of 53BP1 on homologous recombination and affects PARP inhibitor resistance. Oncogene (2022) 41, 2706-2718. [PubMed]
  • Yamada C, Morooka A, Miyazaki S, Nagai M, Mase S, Iemura K, Tasnin MN, Takuma T, Nakamura S, Morshed S, Koike N, Mostofa MG, Rahman MA, Sharmin T, Katsuta H, Ohara K, Tanaka K, Ushimaru T. TORC1 inactivation promotes APC/C-dependent mitotic slippage in yeast and human cells. iScience (2022) 25, 103675. [PubMed]
  • Iemura K, Yoshizaki Y, Kuniyasu K, Tanaka K. Attenuated chromosome oscillation as a cause of chromosomal instability in cancer cells. Cancers (2021) 13, 4531. [PubMed]
  • Campos Medina M, Iemura K, Kimura A, Tanaka K. A mathematical model of kinetochore-microtubule attachment regulated by Aurora A activity gradient describes chromosome oscillation and correction of erroneous attachments. Biomed Res (2021) 42, 203-219. [PubMed]
  • Hino M, Iemura K, Ikeda M, Itoh G, Tanaka K. CHAMP1 (CAMP) plays a role in cell survival through regulating Mcl-1 expression. Cancer Sci (2021) 112, 3711-3721. [PubMed]
  • Iemura K, Natsume T, Maehara K, Kanemaki MT, Tanaka K. Chromosome oscillation promotes Aurora A-dependent Hec1 phosphorylation and mitotic fidelity. J Cell Biol (2021) 220, e202006116. [PubMed]
  • Nishizawa H, Matsumoto M, Chen G, Ishi Y, Keisuke T, Onodera M, Kato H, Muto A, Tanaka K, Igarashi K. Lipid peroxidation and the subsequent cell death transmitting from ferroptotic cells to neighboring cells. Cell Death Dis(2021) 12, 332. [PubMed]
  • Uchida KSK, Jo M, Nagasaka K, Takahashi M, Shindo N, Shibata K, Tanaka K, Masumoto H, Fukagawa T, Hirota T. Kinetochore stretching-mediated rapid silencing of the spindle-assembly checkpoint required for failsafe chromosome segregation. Curr Biol (2021) 31, 1581-1591
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  • Itoh S, Goto H, Kuniyasu K, Shindo M, Yamada M, Tanaka K, Toh GT, Sawa M, Inagaki M, Bartek J, Masai H. Cdc7 kinase stimulates Aurora B kinase in M-phase. Sci Rep (2019) 9, 18622. [PubMed]
  • Kuniyasu K, Iemura K, Tanaka K. Delayed chromosome alignment to the spindle equator increases the rate of chromosome missegregation in cancer cells. Biomolecules (2018) 9, 10 (in the special issue "Cytoskeleton and Regulation of Mitosis"[Special issue website]). [PubMed][Issue Cover]
  • Konishi M, Shindo T, Komiya M, Tanaka K, Itoh T, Hirota T. Quantitative analysis of the metaphase-to-anaphase transition reveal differential kinetic regulation for securin and cyclin B1. Biomed Res (2018) 8, 7003. [PubMed]
  • Itoh G*, Ikeda M* (*equally contributors), Iemura K, Amin MA, Kurimiya S, Tanaka M, Mizuno N, Osakada H, Haraguchi T, Tanaka K. Lateral attachment of kinetochores to microtubules is enriched in prometaphase rosette and facilitates chromosome alignment and bi-orientation establishment. Sci Rep (2018) 8, 3888. [PubMed]
  • Li J, Shima H, Nishizawa H, Ikeda M, Brydun A, Matsumoto M, Kato H, Saiki Y, Liu L, Watanabe-Matsui M, Iemura K, Tanaka K, Shiraki T, Igarashi K. Phosphorylation of BACH1 switches its function from transcription factor to mitotic chromosome regulator and promotes its interaction with HMMR.Biochem J (2018) 475, 981. [PubMed]
  • Hara K, Taharazako S, Ikeda M, Fujita H, Mikami Y, Kikuchi S, Hishiki A, Yokoyama H, Ishikawa Y, Kanno SI, Tanaka K, Hashimoto H. Dynamic feature of mitotic arrest deficient 2-like protein 2 (MAD2L2) and structural basis for its interaction with chromosome alignment maintaining phosphoprotein (CAMP). J Biol Chem (2017) 292, 17658. [PubMed]
  • Ikeda, M, and Tanaka, K. Plk1 bound to Bub1 contributes to spindle assembly checkpoint activity during mitosis. Sci Rep (2017) 7, 8794. [PubMed]
  • Asai Y, Yamada T, Tsukita S, Takahashi K, Maekawa M, Honma M, Ikeda M, Murakami K, Munakata Y, Shirai Y, Kodama S, Sugisawa T, Chiba Y, Kondo Y, Kaneko K, Uno K, Sawada S, Imai J, Nakamura Y, Yamaguchi H, Tanaka K, Sasano H, Mano N, Ueno Y, Shimosegawa T, Katagiri H. Activation of the Hypoxia Inducible Factor 1 alpha subunit pathway in steatotic liver contributes to formation of cholesterol gallstones. Gastroenterology (2017) 152, 1521. [PubMed]
  • Takahashi, M, Tanaka, K, Wakai, T, and Hirota, T. Phosphoproteomic analysis of human mitotic chromosomes identified a chromokinesin KIF4A.Biomed Res (2016) 37, 161-165. [PubMed]
  • Hasanpourghadi, M, Karthikeyan, C, Pandurangan, A, K, Looi, C, Y, Trivedi, P, Kobayashi, K, Tanaka, K, Wong W, F, Mustafa, M, R. Targeting of tubulin polymerization and induction of mitotic blockage by Methyl 2-(5-fluoro-2-hydroxyphenyl)-1H-benzo[d]imidazole-5-carboxylate (MBIC) in human cervical cancer HeLa cell. J Exp Clin Cancer Res (2016) 35, 58. [PubMed]
  • Isidor, B*, Küry, S* (*equally contributors), Rosenfeld, J, A, Besnard, T, Schmitt, S, Joss, S, Davies, S, J, Lebel, R, R, Henderson, A, Schaaf, C, P, Streff, H, E, Yang, Y, Jain, V, Chida, N, Latypova, X, Caignec, C, L, Cogné, B, Mercier, S, Vincent, M, Colin, E, Bonneau, D, Denommé, A, S, Parent, P, Gilbert-Dussardier, B, Odent, S, Toutain, A, Piton, A, Dina, C, Donnart, A, Lindenbaum, P, Charpentier, E, Redon, R, Iemura, K, Ikeda, M, Tanaka, K✝, Bézieau, S✝ (✝equally contributors). De Novo Truncating Mutations in the kinetochore-microtubules attachment gene CHAMP1 Cause Syndromic Intellectual Disability. Hum Mutat (2016) 37, 354-358. [PubMed]
  • Amin, M, A, Kobayashi, K, and Tanaka, K. CLIP-170 tethers kinetochores to microtubule plus ends against poleward force by dynein for stable kinetochore-microtubule attachment. FEBS Lett (2015) 589, 2739-2746. [PubMed]
  • Ohira, M, Iwasaki, Y, Tanaka, C, Kuroki, M, Matsuo, N, Kitamura, T, Yukuhiro, M, Morimoto, H, Pang, N, Liu, B, Kiyono, T, Amemiya, M, Tanaka, K, Yoshida, K, Sugimoto, N, Ohshima, T, Fujita, M. A novel anti-microtubule agent with carbazole and benzohydrazide structures suppresses tumor cell growth in vivo. Biochim Biophys Acta (2015) 1850, 1676-1684. [PubMed]
  • Iemura, K, and Tanaka, K. Chromokinesin Kid and kinetochore kinesin CENP-E differentially support chromosome congression without end-on attachment to microtubules. Nature Communications (2015) 6, 6447. [PubMed]
  • Amin, M, A, Itoh, G, Iemura, K, Ikeda, M, and Tanaka, K. CLIP-170 is required to recruit PLK1 to kinetochores during early mitosis for chromosome alignment. J Cell Sci (2014) 127, 2818-2824. [PubMed]
  • Itoh, G*, Sugino, S*, Ikeda, M* (*equally contributors), Mizuguchi, M, Kanno, S, I, Amin, M, A, Iemura, K, Yasui, A, Hirota, T, and Tanaka, K. The nucleoporin Nup188 is required for chromosome alignment in mitosis. Cancer Sci (2013) 104, 871-879. [PubMed]
  • Gandhi, S, R, Gierlinski, M, Mino, A, Tanaka, K, Kitamura, E, Clayton, L, and Tanaka, T, U. Kinetochore-dependent microtubule rescue ensures their efficient and sustained interactions in early mitosis. Dev Cell (2011) 21, 920-933. [PubMed]
  • Kawashima, S*, Nakabayashi, Y* (*equally contributors), Matsubara, K, Sano, N, Enomoto, T, Tanaka, K**, Seki, M**, and Horikoshi, M** (**corresponding authors). Global analysis of core histones reveals nucleosomal surfaces required for chromosome bi-orientation. EMBO J (2011) 30, 3353-3367. [PubMed]
  • Itoh, G, Kanno, S, Uchida, K, Chiba, S, Sugino, A, Watanabe, K, Mizuno, K, Yasui, A, Hirota, T, and Tanaka, K. CAMP (C13orf8, ZNF828) is a novel regulator of kinetochore-microtubule attachment. EMBO J (2011) 30, 130-144. [PubMed][Tohoku University website]
  • Endo, K, Mizuguchi, M, Harata, A, Itoh, G, and Tanaka, K. Nocodazole induces mitotic cell death with apoptotic-like features in Saccharomyces cerevisiae. FEBS Lett, (2010) 584, 2387-2392. [PubMed]
  • Kitamura, E*, Tanaka, K*, Komoto, S* (*equally contributors), Kitamura, Y, Antony, C, and Tanaka, T, U. Kinetochores generate microtubules with distal plus ends: their roles and limited lifetime in mitosis. Dev Cell (2010) 18, 248-259. [PubMed]
  • Sarai, N, Kagawa, W, Fujikawa, N, Saito, K, Hikiba, J, Tanaka, K, Miyagawa, K, Kurumizaka, H, and Yokoyama, S. Biochemical analysis of the N-terminal domain of human RAD54B. Nucleic Acids Res (2008) 36, 5441-5450. [PubMed]
  • Romao, M, Tanaka, K, Sibarita J, B, Ly-Hartig, N, T, Tanaka, T, U, and Antony, C. Three-dimensional electron microscopy analysis of ndc10-1 mutant reveals an aberrant organization of the mitotic spindle and spindle pole defects in Saccharomyces cerevisiae. J Struct Biol (2008) 163, 18-28. [PubMed]
    Kitamura, E, Tanaka, K, Kitamura, Y, and Tanaka, T, U. Kinetochore-microtubule interaction during S phase in Saccharomyces cerevisiae. Genes Dev (2007) 21, 3319-3330. [PubMed]
    Tanaka, K, Kitamura, E, Kitamura, Y, and Tanaka, T, U. Molecular mechanisms of microtubule-dependent kinetochore transport towards spindle poles. J Cell Biol (2007) 178, 269-281. [PubMed]
    Valga, V, Helenius, J, Tanaka, K, Hyman A, A, Tanaka, T, U, and Howard J. Yeast kinesin-8 depolymerizes microtubules in a length-dependent manner. Nat Cell Biol (2006) 8, 957-962. [PubMed]
    Sarai, N, Kagawa, W, Kinebuchi, T, Kagawa, A, Tanaka, K, Miyagawa, K, Ikawa, S, Shibata, T, Kurumizaka, H, and Yokoyama, S. Stimulation of Dmc1-mediated DNA Strand Exchange by the Human Rad54B Protein. Nucleic Acids Res (2006) 34, 4429-4437. [PubMed]
    Tanaka, K, Mukae, N, Dewar, H, van Breugel, M, James, E, K, Prescott, A, R, Antony, C, and Tanaka, T, U. Molecular mechanisms for kinetochore capture by spindle microtubules. Nature (2005) 434, 987-994. [PubMed]
    Dewar, H, Tanaka, K, Nasmyth, K, and Tanaka, T, U. Tension between two kinetochores suffices for their bi-orientation on the mitotic spindle. Nature (2004) 428, 93-97. [PubMed]
    Kinebuchi, T, Kagawa, W, Enomoto, R, Tanaka, K, Miyagawa, K, Shibata, T, Kurumizaka, H, and Yokoyama, S. Structural basis for octameric ring formation and DNA interaction of the human homologous-pairing protein Dmc1. Mol Cell (2004) 14, 363-374. [PubMed]


  • Qian, J, Zhou, X, Tanaka, K, Takahashi, A. Alteration in the chromatin landscape during the DNA damage response: Continuous rotation of the gear driving cellular senescence and aging. DNA Repair (2023) 131, 103572. [PubMed]
  • Tanaka K, Goto H, Nishimura Y, Kasahara K, Mizoguchi A, Inagaki M. Tetraploidy in cancer and its possible link to aging. Cancer Sci (2018) 109, 2632-2640. [PubMed]
  • Tanaka, K, and Hirota, T. Chromosomal Instability: A common feature and a therapeutic target of cancer. Biochim Biophys Acta (2016) 1866, 64-75. [PubMed]
  • Tanaka, K. Mitosis. eLS (2015), DOI: 10.1002/9780470015902.a0001356.pub2. [eLS]
  • Tanaka, K. Regulatory mechanisms of kinetochore-microtubule interaction in mitosis. Cell Mol Life Sci (2013) 70, 559-579. [PubMed]
  • Tanaka, K. Dynamic regulation of kinetochore-microtubule interaction during mitosis. J Biochem (2012) 152, 415-424. [PubMed]
  • Tanaka, K, Kitamura, E, and Tanaka, T, U. Live cell analysis of kinetochore-microtubules interaction in budding yeast. Methods (2010) 51, 206-213. [PubMed]
    Tanaka, K, and Hirota, T. Chromosome segregation machinery and cancer. Cancer Sci (2009) 100, 1158-1165. [PubMed]
    Tanaka, K, and Tanaka, T, U. Live cell imaging of kinetochore capture by microtubules in budding yeast. Methods Mol Biol (2009) 545, 233-242. [PubMed]
    Tanaka, T, U, Stark, M, J, and, Tanaka, K. Kinetochore capture and bi-orientation on the mitotic spindle. Nat Rev Mol Cell Biol (2005) 6, 929-942. [PubMed]