田中耕三 研究室 Department of Molecular Oncology-研究業績

English

研究業績

原著論文(2004年以降)

  • Hara K, Taharazako S, Ikeda M, Fujita H, Mikami Y, Kikuchi S, Hishiki A, Yokoyama H, Ishikawa Y, Kanno SI, Tanaka K, Hashimoto H. Dynamic feature of mitotic arrest deficient 2-like protein 2 (MAD2L2) and structural basis for its interaction with chromosome alignment maintaining phosphoprotein (CAMP). J Biol Chem (2017) 292, 17658. [PubMed]
  • Ikeda, M, and Tanaka, K. Plk1 bound to Bub1 contributes to spindle assembly checkpoint activity during mitosis. Sci Rep (2017) 7, 8794. [PubMed][加齢研ホームページ]LinkIcon
  • Asai Y, Yamada T, Tsukita S, Takahashi K, Maekawa M, Honma M, Ikeda M, Murakami K, Munakata Y, Shirai Y, Kodama S, Sugisawa T, Chiba Y, Kondo Y, Kaneko K, Uno K, Sawada S, Imai J, Nakamura Y, Yamaguchi H, Tanaka K, Sasano H, Mano N, Ueno Y, Shimosegawa T, Katagiri H. Activation of the Hypoxia Inducible Factor 1 alpha subunit pathway in steatotic liver contributes to formation of cholesterol gallstones. Gastroenterology (2017) 152, 1521. [PubMed]
  • Takahashi, M, Tanaka, K, Wakai, T, and Hirota, T. Phosphoproteomic analysis of human mitotic chromosomes identified a chromokinesin KIF4A. Biomed Res (2016) 37, 161-165. [PubMed]
  • Hasanpourghadi, M, Karthikeyan, C, Pandurangan, A, K, Looi, C, Y, Trivedi, P, Kobayashi, K, Tanaka, K, Wong W, F, Mustafa, M, R. Targeting of tubulin polymerization and induction of mitotic blockage by Methyl 2-(5-fluoro-2-hydroxyphenyl)-1H-benzo[d]imidazole-5-carboxylate (MBIC) in human cervical cancer HeLa cell. J Exp Clin Cancer Res (2016) 35, 58. [PubMed]
  • Isidor, B*, Küry, S* (*equally contributors), Rosenfeld, J, A, Besnard, T, Schmitt, S, Joss, S, Davies, S, J, Lebel, R, R, Henderson, A, Schaaf, C, P, Streff, H, E, Yang, Y, Jain, V, Chida, N, Latypova, X, Caignec, C, L, Cogné, B, Mercier, S, Vincent, M, Colin, E, Bonneau, D, Denommé, A, S, Parent, P, Gilbert-Dussardier, B, Odent, S, Toutain, A, Piton, A, Dina, C, Donnart, A, Lindenbaum, P, Charpentier, E, Redon, R, Iemura, K, Ikeda, M, Tanaka, K✝, Bézieau, S✝ (✝equally contributors). De Novo Truncating Mutations in the kinetochore-microtubules attachment gene CHAMP1 Cause Syndromic Intellectual Disability. Hum Mutat (2016) 37, 354-358. [PubMed][加齢研ホームページ]LinkIcon
  • Amin, M, A, Kobayashi, K, and Tanaka, K. CLIP-170 tethers kinetochores to microtubule plus ends against poleward force by dynein for stable kinetochore-microtubule attachment. FEBS Lett (2015) 589, 2739-2746. [PubMed]
  • Ohira, M, Iwasaki, Y, Tanaka, C, Kuroki, M, Matsuo, N, Kitamura, T, Yukuhiro, M, Morimoto, H, Pang, N, Liu, B, Kiyono, T, Amemiya, M, Tanaka, K, Yoshida, K, Sugimoto, N, Ohshima, T, Fujita, M. A novel anti-microtubule agent with carbazole and benzohydrazide structures suppresses tumor cell growth in vivo. Biochim Biophys Acta (2015) 1850, 1676-1684. [PubMed]
  • Iemura, K, and Tanaka, K. Chromokinesin Kid and kinetochore kinesin CENP-E differentially support chromosome congression without end-on attachment to microtubules. Nature Communications (2015) 6, 6447. [PubMed][プレスリリース][加齢研ホームページ]
  • Amin, M, A, Itoh, G, Iemura, K, Ikeda, M, and Tanaka, K. CLIP-170 is required to recruit PLK1 to kinetochores during early mitosis for chromosome alignment. J Cell Sci (2014) 127, 2818-2824. [PubMed]
  • Itoh, G*, Sugino, S*, Ikeda, M* (*equally contributors), Mizuguchi, M, Kanno, S, I, Amin, M, A, Iemura, K, Yasui, A, Hirota, T, and Tanaka, K. The nucleoporin Nup188 is required for chromosome alignment in mitosis. Cancer Sci (2013) 104, 871-879. [PubMed]
  • Gandhi, S, R, Gierlinski, M, Mino, A, Tanaka, K, Kitamura, E, Clayton, L, and Tanaka, T, U. Kinetochore-dependent microtubule rescue ensures their efficient and sustained interactions in early mitosis. Dev Cell (2011) 21, 920-933. [PubMed]
  • Kawashima, S*, Nakabayashi, Y* (*equally contributors), Matsubara, K, Sano, N, Enomoto, T, Tanaka, K**, Seki, M**, and Horikoshi, M** (**corresponding authors). Global analysis of core histones reveals nucleosomal surfaces required for chromosome bi-orientation. EMBO J (2011) 30, 3353-3367. [PubMed][Biotechnology Japan]
  • Itoh, G, Kanno, S, Uchida, K, Chiba, S, Sugino, A, Watanabe, K, Mizuno, K, Yasui, A, Hirota, T, and Tanaka, K. CAMP (C13orf8, ZNF828) is a novel regulator of kinetochore-microtubule attachment. EMBO J (2011) 30, 130-144. [PubMed][東北大学ホームページ][加齢研ホームページ]
  • Endo, K, Mizuguchi, M, Harata, A, Itoh, G, and Tanaka, K. Nocodazole induces mitotic cell death with apoptotic-like features in Saccharomyces cerevisiae. FEBS Lett, (2010) 584, 2387-2392. [PubMed]
  • Kitamura, E*, Tanaka, K*, Komoto, S* (*equally contributors), Kitamura, Y, Antony, C, and Tanaka, T, U. Kinetochores generate microtubules with distal plus ends: their roles and limited lifetime in mitosis. Dev Cell (2010) 18, 248-259. [PubMed]
  • Sarai, N, Kagawa, W, Fujikawa, N, Saito, K, Hikiba, J, Tanaka, K, Miyagawa, K, Kurumizaka, H, and Yokoyama, S. Biochemical analysis of the N-terminal domain of human RAD54B. Nucleic Acids Res (2008) 36, 5441-5450. [PubMed]
  • Romao, M, Tanaka, K, Sibarita J, B, Ly-Hartig, N, T, Tanaka, T, U, and Antony, C. Three-dimensional electron microscopy analysis of ndc10-1 mutant reveals an aberrant organization of the mitotic spindle and spindle pole defects in Saccharomyces cerevisiae. J Struct Biol (2008) 163, 18-28. [PubMed]
    Kitamura, E, Tanaka, K, Kitamura, Y, and Tanaka, T, U. Kinetochore-microtubule interaction during S phase in Saccharomyces cerevisiae. Genes Dev (2007) 21, 3319-3330. [PubMed]
    Tanaka, K, Kitamura, E, Kitamura, Y, and Tanaka, T, U. Molecular mechanisms of microtubule-dependent kinetochore transport towards spindle poles. J Cell Biol (2007) 178, 269-281. [PubMed]
    Valga, V, Helenius, J, Tanaka, K, Hyman A, A, Tanaka, T, U, and Howard J. Yeast kinesin-8 depolymerizes microtubules in a length-dependent manner. Nat Cell Biol (2006) 8, 957-962. [PubMed]
    Sarai, N, Kagawa, W, Kinebuchi, T, Kagawa, A, Tanaka, K, Miyagawa, K, Ikawa, S, Shibata, T, Kurumizaka, H, and Yokoyama, S. Stimulation of Dmc1-mediated DNA Strand Exchange by the Human Rad54B Protein. Nucleic Acids Res (2006) 34, 4429-4437. [PubMed]
    Tanaka, K, Mukae, N, Dewar, H, van Breugel, M, James, E, K, Prescott, A, R, Antony, C, and Tanaka, T, U. Molecular mechanisms for kinetochore capture by spindle microtubules. Nature (2005) 434, 987-994. [PubMed]
    Dewar, H, Tanaka, K, Nasmyth, K, and Tanaka, T, U. Tension between two kinetochores suffices for their bi-orientation on the mitotic spindle. Nature (2004) 428, 93-97. [PubMed]
    Kinebuchi, T, Kagawa, W, Enomoto, R, Tanaka, K, Miyagawa, K, Shibata, T, Kurumizaka, H, and Yokoyama, S. Structural basis for octameric ring formation and DNA interaction of the human homologous-pairing protein Dmc1. Mol Cell (2004) 14, 363-374. [PubMed]

総説

  • Tanaka, K, and Hirota, T. Chromosomal Instability: A common feature and a therapeutic target of cancer. Biochim Biophys Acta (2016) 1866, 64-75. [PubMed]
  • Tanaka, K. Mitosis. eLS (2015), DOI: 10.1002/9780470015902.a0001356.pub2. [eLS]
  • Tanaka, K. Regulatory mechanisms of kinetochore-microtubule interaction in mitosis. Cell Mol Life Sci (2013) 70, 559-579. [PubMed]
  • Tanaka, K. Dynamic regulation of kinetochore-microtubule interaction during mitosis. J Biochem (2012) 152, 415-424. [PubMed]
  • Tanaka, K, Kitamura, E, and Tanaka, T, U. Live cell analysis of kinetochore-microtubules interaction in budding yeast. Methods (2010) 51, 206-213. [PubMed]
    Tanaka, K, and Hirota, T. Chromosome segregation machinery and cancer. Cancer Sci (2009) 100, 1158-1165. [PubMed]
    Tanaka, K, and Tanaka, T, U. Live cell imaging of kinetochore capture by microtubules in budding yeast. Methods Mol Biol (2009) 545, 233-242. [PubMed]
    Tanaka, T, U, Stark, M, J, and, Tanaka, K. Kinetochore capture and bi-orientation on the mitotic spindle. Nat Rev Mol Cell Biol (2005) 6, 929-942. [PubMed]
  • 田中耕三. 染色体不安定性とがん. 血液内科 (2017) 75, 117-122.
  • 家村顕自, 田中耕三. 分裂期において染色体を効率よく運ぶための仕組み. 生化学 (2017) 89, 102-105.
  • 田中耕三. 1枚の写真館 「側面結合」との出会い. 細胞工学 (2016) 35, 95.
  • 田中耕三. 治療標的としてのAuroraキナーゼによる動原体制御. 血液内科 (2015) 71, 712-717.
  • 田中耕三. 特集 染色体安定性制御と疾患 総論 染色体不安定性の病態生理. 細胞(2015)47, 212-214.
  • 田中耕三. 分裂期チェックポイントアダプテーション阻害による抗がん剤耐性克服. 次世代がん戦略研究 Update がん基盤生物学(2013)193-199.
  • 田中耕三. Mad2/Mad2L2(Rev7)の構造と機能. 生化学(2013)85, 629-637. [PubMed]
  • 田中耕三. 染色体分配を司る動原体と微小管の相互作用. 細胞工学 (2013) 32, 291-296.
  • 田中耕三. 染色体分配の分子機構と関連分子を標的としたがん治療への展望. 実験医学 (2012) 30, 3118-3124.
  • 田中耕三, 田中智之. 微小管によるキネトコア捕捉の分子機構. 実験医学 (2007) 25, 671-678.
    田中耕三, 田中智之. 動原体-微小管結合の分子機構. 蛋白質 核酸 酵素 (2006) 51, 1-9. [PubMed}